lotilaner — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. lotilaner is a isoxazoline ectoparasiticide (flea/tick).
Total reports
lotilaner: 13432
Reports by species (top entries)
- Dog 11534
- Cat 859
- Human 27
- Cattle 1
- Pig 1
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 3355
- Diarrhoea 1586
- UNPALATABLE 906
- Other abnormal test result NOS 848
- Lack of efficacy (ectoparasite) - tick NOS 759
- Seizure NOS 729
- Lack of efficacy (bacteria) - Borrelia 707
- Lethargy (see also Central nervous system depression in Neurological) 676
- Lethargy (see also Central nervous system depression in 'Neurological') 667
- Lack of efficacy (ectoparasite) - flea 637
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).