{"topic_id":"ade_lotilaner_adverse_events","category":"ade","context":"---\ntopic_id: ade_lotilaner_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for lotilaner (isoxazoline ectoparasiticide (flea/tick)) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-21\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-21.json\ndate_parsed: 2026-07-21\ntokens_estimated: 214\nverification:\n  method: substring_match\n  claims: 32\n  passed: 32\n  date: 2026-07-21\n---\n\n# lotilaner — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. lotilaner is a isoxazoline ectoparasiticide (flea/tick).\n\n## Total reports\nlotilaner: 13432\n\n## Reports by species (top entries)\n- Dog 11534\n- Cat 859\n- Human 27\n- Cattle 1\n- Pig 1\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Vomiting 3355\n- Diarrhoea 1586\n- UNPALATABLE 906\n- Other abnormal test result NOS 848\n- Lack of efficacy (ectoparasite) - tick NOS 759\n- Seizure NOS 729\n- Lack of efficacy (bacteria) - Borrelia 707\n- Lethargy (see also Central nervous system depression in Neurological) 676\n- Lethargy (see also Central nervous system depression in 'Neurological') 667\n- Lack of efficacy (ectoparasite) - flea 637\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-21.json` (openFDA animalandveterinary/event.json, pulled 2026-07-21).\n","sources":[],"tokens_estimated":214,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}