hyaluronic acid — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-08-16. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. "hyaluronic acid" is a name as filed in the drug active-ingredient field of these reports (may be a generic ingredient or a product/brand name as reported).
Total reports
hyaluronic acid: 392
Reports by species (top entries)
- Dog 193
- Horse 50
- Cat 10
- Human 2
- Guinea Pig 1
- Other 1
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 33
- Diarrhoea 27
- Lack of efficacy - NOS 27
- Lethargy (see also Central nervous system depression in 'Neurological') 25
- Ocular discharge 21
- Corneal ulcer 20
- Lameness 18
- Other abnormal test result NOS 18
- Behavioural disorder NOS 17
- Underfilling, Bottles 16
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json (openFDA animalandveterinary/event.json, pulled 2026-08-16).