{"topic_id":"ade_hyaluronic_acid_adverse_events","category":"ade","context":"---\ntopic_id: ade_hyaluronic_acid_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for hyaluronic acid — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-08-16\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json\ndate_parsed: 2026-08-16\ntokens_estimated: 200\nverification:\n  method: derived_from_dataset\n  claims: 17\n  note: \"Values are report-level aggregates computed from the cited openFDA JSON source; not verbatim substrings. Counts are not additive (one report may list multiple reactions/animals).\"\n  date: 2026-08-16\nsource_document: \"FDA FAERS / openFDA Animal & Veterinary Event Reports\"\ncitation:\n  authority: \"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)\"\n  title: \"FDA ADE reports for hyaluronic acid — total reports, species & reaction breakdown\"\n  url: \"\"\n  retrieved: \"2026-08-16\"\n  ref: \"\"\n  doc_type: \"open dataset (JSON API)\"\n  needs_review: true\nauthority_tier: T1\nauthority_tier_basis: \"T1:fda\"\nauthority_tier_date: 2026-08-16\n---\n\n# hyaluronic acid — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-08-16. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. \"hyaluronic acid\" is a name as filed in the drug active-ingredient field of these reports (may be a generic ingredient or a product/brand name as reported).\n\n## Total reports\nhyaluronic acid: 392\n\n## Reports by species (top entries)\n- Dog 193\n- Horse 50\n- Cat 10\n- Human 2\n- Guinea Pig 1\n- Other 1\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Vomiting 33\n- Diarrhoea 27\n- Lack of efficacy - NOS 27\n- Lethargy (see also Central nervous system depression in 'Neurological') 25\n- Ocular discharge 21\n- Corneal ulcer 20\n- Lameness 18\n- Other abnormal test result NOS 18\n- Behavioural disorder NOS 17\n- Underfilling, Bottles 16\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json` (openFDA animalandveterinary/event.json, pulled 2026-08-16).\n","sources":["US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database) — FDA ADE reports for hyaluronic acid — total reports, species & reaction breakdown (retrieved 2026-08-16)"],"source":{"authority":"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)","title":"FDA ADE reports for hyaluronic acid — total reports, species & reaction breakdown","url":"https://open.fda.gov/data/animal-and-veterinary/","retrieved":"2026-08-16","ref":"","doc_type":"open dataset (JSON API)","source_document":"FDA FAERS / openFDA Animal & Veterinary Event Reports","verification_file":"pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json"},"source_document":"FDA FAERS / openFDA Animal & Veterinary Event Reports","source_file":"pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json","trust":{"authority_tier":"T1","fidelity":"verbatim","license":null,"display_grade":"A"},"tokens_estimated":200,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}