fluralaner — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. fluralaner is a isoxazoline ectoparasiticide (flea/tick).
Total reports
fluralaner: 88486
Reports by species (top entries)
- Dog 65708
- Cat 13343
- Human 1288
- Rabbit 6
- Fox 3
- Goat 3
Top reported reactions (VEDDRA terms, top entries)
- Vomiting 20360
- Lack of efficacy (ectoparasite) - flea 17108
- Emesis (multiple) 6345
- Lethargy (see also Central nervous system depression in 'Neurological') 6117
- Lack of efficacy (ectoparasite) - tick NOS 5244
- Diarrhoea 4741
- UNPALATABLE 4069
- Seizure NOS 3347
- Application site hair loss 2487
- Product Defect, General 2323
"Lack of efficacy" terms denote product-performance reports, not adverse reactions.
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).