{"topic_id":"ade_fluralaner_adverse_events","category":"ade","context":"---\ntopic_id: ade_fluralaner_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for fluralaner (isoxazoline ectoparasiticide (flea/tick)) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-21\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-21.json\ndate_parsed: 2026-07-21\ntokens_estimated: 206\nverification:\n  method: substring_match\n  claims: 34\n  passed: 34\n  date: 2026-07-21\n---\n\n# fluralaner — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. fluralaner is a isoxazoline ectoparasiticide (flea/tick).\n\n## Total reports\nfluralaner: 88486\n\n## Reports by species (top entries)\n- Dog 65708\n- Cat 13343\n- Human 1288\n- Rabbit 6\n- Fox 3\n- Goat 3\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Vomiting 20360\n- Lack of efficacy (ectoparasite) - flea 17108\n- Emesis (multiple) 6345\n- Lethargy (see also Central nervous system depression in 'Neurological') 6117\n- Lack of efficacy (ectoparasite) - tick NOS 5244\n- Diarrhoea 4741\n- UNPALATABLE 4069\n- Seizure NOS 3347\n- Application site hair loss 2487\n- Product Defect, General 2323\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-21.json` (openFDA animalandveterinary/event.json, pulled 2026-07-21).\n","sources":[],"tokens_estimated":206,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}