FDA ADE reports for fipronil (phenylpyrazole ectoparasiticide (flea/tick)) — total reports, species & reaction breakdown

ade_fipronil_adverse_events

ade 201 tok en 2026-07-21

fipronil — FDA Animal & Veterinary Adverse Event (ADE) Reports

Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. fipronil is a phenylpyrazole ectoparasiticide (flea/tick).

Total reports

fipronil: 7093

Reports by species (top entries)

Dog 6173
Cat 904
Human 4
Other Canids 4
Goat 1
Other 1

Top reported reactions (VEDDRA terms, top entries)

Lack of efficacy (ectoparasite) - flea 1279
Lethargy (see also Central nervous system depression in 'Neurological') 1122
Vomiting 1005
Diarrhoea 461
Emesis 408
Behavioural disorder NOS 395
Seizure NOS 374
Lack of efficacy - NOS 290
Panting 269
Scratching 262

"Lack of efficacy" terms denote product-performance reports, not adverse reactions.

Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-21.json (openFDA animalandveterinary/event.json, pulled 2026-07-21).

Sources

openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-21

Machine access

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Raw JSON ↗ llm.txt OpenAPI