{"topic_id":"ade_fipronil_adverse_events","category":"ade","context":"---\ntopic_id: ade_fipronil_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for fipronil (phenylpyrazole ectoparasiticide (flea/tick)) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-21\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-21.json\ndate_parsed: 2026-07-21\ntokens_estimated: 201\nverification:\n  method: substring_match\n  claims: 34\n  passed: 34\n  date: 2026-07-21\n---\n\n# fipronil — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. fipronil is a phenylpyrazole ectoparasiticide (flea/tick).\n\n## Total reports\nfipronil: 7093\n\n## Reports by species (top entries)\n- Dog 6173\n- Cat 904\n- Human 4\n- Other Canids 4\n- Goat 1\n- Other 1\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Lack of efficacy (ectoparasite) - flea 1279\n- Lethargy (see also Central nervous system depression in 'Neurological') 1122\n- Vomiting 1005\n- Diarrhoea 461\n- Emesis 408\n- Behavioural disorder NOS 395\n- Seizure NOS 374\n- Lack of efficacy - NOS 290\n- Panting 269\n- Scratching 262\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-21.json` (openFDA animalandveterinary/event.json, pulled 2026-07-21).\n","sources":[],"tokens_estimated":201,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}