FDA ADE reports for Buprenorphine (opioid analgesic (dogs & cats)) — total reports, species & reaction breakdown

ade_buprenorphine_adverse_events

ade en 2026-07-22

Buprenorphine — FDA Animal & Veterinary Adverse Event (ADE) Reports

Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Buprenorphine is a opioid analgesic (dogs & cats).

Total reports

Buprenorphine: 6944

Reports by species (top entries)

Cat 5308
Dog 1343
Human 61
Rabbit 30
Mouse 11
Rat 6

Top reported reactions (VEDDRA terms, top entries)

Behavioural disorder NOS 987
Not eating 756
Dilated pupils 721
Anorexia 592
Hyperactivity 571
Lethargy (see also Central nervous system depression in 'Neurological') 561
Death 551
Dysphoria 521
Vomiting 450
Death by euthanasia 436

"Lack of efficacy" terms denote product-performance reports, not adverse reactions.

Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b8.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).

Sources

openFDA animalandveterinary/event.json (FDA CVM ADE), pulled 2026-07-22

Machine access

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