{"topic_id":"ade_buprenorphine_adverse_events","category":"ade","context":"---\ntopic_id: ade_buprenorphine_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for Buprenorphine (opioid analgesic (dogs & cats)) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-22\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-22_b8.json\ndate_parsed: 2026-07-22\ntokens_estimated: 196\nverification:\n  method: substring_match\n  claims: 34\n  passed: 34\n  date: 2026-07-22\n---\n\n# Buprenorphine — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Buprenorphine is a opioid analgesic (dogs & cats).\n\n## Total reports\nBuprenorphine: 6944\n\n## Reports by species (top entries)\n- Cat 5308\n- Dog 1343\n- Human 61\n- Rabbit 30\n- Mouse 11\n- Rat 6\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Behavioural disorder NOS 987\n- Not eating 756\n- Dilated pupils 721\n- Anorexia 592\n- Hyperactivity 571\n- Lethargy (see also Central nervous system depression in 'Neurological') 561\n- Death 551\n- Dysphoria 521\n- Vomiting 450\n- Death by euthanasia 436\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-22_b8.json` (openFDA animalandveterinary/event.json, pulled 2026-07-22).\n","sources":[],"tokens_estimated":269,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}