Bupivacaine — FDA Animal & Veterinary Adverse Event (ADE) Reports
Source: openFDA animalandveterinary/event.json, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Bupivacaine is a active ingredient.
Total reports
Bupivacaine: 627
Reports by species (top entries)
- Cat 232
- Dog 223
- Human 12
- Pig 2
- Rabbit 2
- Cephalopoda 1
Top reported reactions (VEDDRA terms, top entries)
- Not eating 51
- Vials, Damaged 37
- Behavioural disorder NOS 34
- Decreased appetite 33
- Other abnormal test result NOS 31
- Death 28
- Death by euthanasia 27
- Dilated pupils 26
- Bruising 25
- Lethargy (see also Central nervous system depression in Neurological) 25
Source JSON: pdf-raw/ade/ade_active_ingredients_2026-07-22_b13.json (openFDA animalandveterinary/event.json, pulled 2026-07-22).