{"topic_id":"ade_bupivacaine_adverse_events","category":"ade","context":"---\ntopic_id: ade_bupivacaine_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for Bupivacaine (active ingredient) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-22\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-22_b13.json\ndate_parsed: 2026-07-22\ntokens_estimated: 392\nverification:\n  method: substring_match\n  claims: 34\n  passed: 34\n  date: 2026-07-22\n---\n\n# Bupivacaine — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Bupivacaine is a active ingredient.\n\n## Total reports\nBupivacaine: 627\n\n## Reports by species (top entries)\n- Cat 232\n- Dog 223\n- Human 12\n- Pig 2\n- Rabbit 2\n- Cephalopoda 1\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Not eating 51\n- Vials, Damaged 37\n- Behavioural disorder NOS 34\n- Decreased appetite 33\n- Other abnormal test result NOS 31\n- Death 28\n- Death by euthanasia 27\n- Dilated pupils 26\n- Bruising 25\n- Lethargy (see also Central nervous system depression in Neurological) 25\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-22_b13.json` (openFDA animalandveterinary/event.json, pulled 2026-07-22).\n","sources":[],"tokens_estimated":256,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}