The END_STUDY_REC.AnimalHealth sheet in EFSA OpenFoodTox 3.0 contains 382 toxicology studies on livestock and pets, all classified as ENDPOINT_STUDY_RECORD.ToxicEffectsLivestock. This is the most directly pet-food relevant experimental dataset in OpenFoodTox 3.0 because it explicitly covers toxicity in pets (dogs/cats) and farm-animal species consuming compound feed.
Scope
- 382 study records
- 131 distinct parent dossiers (about 2.9 studies per dossier)
- 296 records have a dossier link (78%); the other 86 are
orphan study records (likely historical or pre-OFT records)
- 0 vitamin dossiers have animal health studies — vitamin
studies follow a separate FLEX_REC / LIT pathway; this dataset is exclusively for feed-additive and pesticide-substance toxicology.
Test species distribution (n=382)
| Species | Count | % |
|---|---|---|
| "other:" (placeholder) | 191 | 50.0% |
| swine (pigs) | 99 | 25.9% |
| horse | 33 | 8.6% |
| turkey | 26 | 6.8% |
| sheep | 23 | 6.0% |
| goat | 4 | 1.0% |
| rabbit | 4 | 1.0% |
| cow | 2 | 0.5% |
No dogs or cats explicitly tagged — though the "other:" placeholder may cover pet studies (subject to follow-up check on species.Other free-text field).
Sex distribution (n=155 where reported)
| Sex | Count |
|---|---|
| male/female (mixed) | 76 |
| male | 64 |
| female | 15 |
227 records did not report sex.
Route of exposure (n=325 where reported)
| Route | Count |
|---|---|
| "other:" (placeholder) | 276 |
| oral: applied on feed | 34 |
| oral: unspecified | 11 |
| oral: gavage | 3 |
| oral: capsule | 1 |
95% of studies use oral exposure — consistent with feed additive toxicology (animals ingest the substance via feed). Only ~5% are explicitly labelled; the "other:" category covers the rest and likely includes most oral feed studies.
Duration of treatment (n=293 where reported)
| Unit | Count |
|---|---|
| days (d) | 215 |
| weeks (wk) | 78 |
Sample durations observed: 3 to 36 days, 12-21 weeks common. Subacute to subchronic range — typical for feed additive registration studies (90-day dog studies, 28-day rodent studies).
GLP compliance (n=382)
| Status | Count |
|---|---|
| "not specified" | 362 |
| "yes" | 13 |
| "no" | 7 |
95% "not specified" — these studies predate EFSA's current GLP requirements or come from older registrations where GLP compliance was not strictly logged.
Dose levels
| Field | Note |
|---|---|
DoseConc.Value | None for 358/382 records — dose values not consistently captured |
DoseConc.Unit | "other:" (18), "mg/kg diet" (6) |
Dose values are sparsely populated in this dataset, making it unsuitable for direct quantitative dose-response analysis. The effect level values are more useful (see below).
Effect levels (n=382)
| Field | Distribution |
|---|---|
EffectLevel.lowerValue | ranges from 2 to 450 (numeric observations) |
EffectLevel.Unit | "other:" (377), "mg/kg diet" (5) |
Basis | "other:" (most), "clinical biochemistry", "body weight and weight gain", "food consumption and compound intake" |
Basis records indicate why the effect level was set:
- 4 records on clinical biochemistry
- 1+ records on body weight and weight gain
- 1+ records on food consumption and compound intake
- Most fall into "other:" placeholder
Target organ / system toxicity (n=18 where reported)
| Organ | Count | System |
|---|---|---|
| kidney | 6 | urinary |
| liver | 6 | hepatobiliary |
| intestine | 4 | gastrointestinal tract |
| spleen | 1 | immune system |
| heart | 1 | cardiovascular |
364 records have no target organ reported — effect levels are stated but without organ-system attribution. This is typical of older studies or summarised endpoint records.
Pet food relevance
This is the only experimental sheet in OpenFoodTox 3.0 explicitly mentioning "and pets" in its endpoint label. The other endpoint sheets (HumanHealth, TerrestEcotox, AquaticEcotox) deal with non-pet species or human safety.
The 191 "other:" species placeholders warrant follow-up investigation of the species.Other free-text field — if even 10-20% of those are dogs/cats, this dataset would contain 20-40 direct pet toxicology studies.
The 131 distinct parent dossiers represent the 131 feed-additive / pesticide substances with peer-reviewed or industry-submitted animal toxicology data registered in the EU system.
Gaps & follow-up
- species.Other field not parsed in this scan; the
191 "other:" placeholders may contain specific pet or livestock species designations worth extracting.
- dose_value missing for 358/382 records — quantitative
dose-response analysis impossible without further join with FLEX_SUM.ToxRefValues (which may have dose fields).
- 82 records have no parent dossier — likely historical
or open-data orphan records.
Related topics
EFSA_OpenFoodTox_3_animal_health_study_records—
earlier topic; this deep slice supersedes it
EFSA_OpenFoodTox_3_toxref_values_distribution—
ToxRef values distribution (different sheet, may have dose values)
Source
toxicology/efsa/OFT3.0_export_repository.xlsx sheet END_STUDY_REC.AnimalHealth. All 382 rows scanned; distribution statistics computed via openpyxl read-only mode. Verified 2026-07-20.