{"topic_id":"EFSA_OpenFoodTox_3_animal_health_tox_studies","category":"efsa","context":"---\ntopic_id: EFSA_OpenFoodTox_3_animal_health_tox_studies\ncategory: efsa\ntitle: EFSA OpenFoodTox 3.0 — 382 AnimalHealth toxicology studies on livestock and pets\nlang: en\nsource: OpenFoodTox 3.0 (Zenodo 19388272), sheet END_STUDY_REC.AnimalHealth\ndate_parsed: 2026-07-20\ntokens_estimated: 540\n---\n\nThe `END_STUDY_REC.AnimalHealth` sheet in EFSA OpenFoodTox 3.0\ncontains **382 toxicology studies on livestock and pets**, all\nclassified as `ENDPOINT_STUDY_RECORD.ToxicEffectsLivestock`.\nThis is the most directly **pet-food relevant** experimental\ndataset in OpenFoodTox 3.0 because it explicitly covers\ntoxicity in pets (dogs/cats) and farm-animal species\nconsuming compound feed.\n\n## Scope\n\n- **382 study records**\n- **131 distinct parent dossiers** (about 2.9 studies per dossier)\n- **296 records have a dossier link** (78%); the other 86 are\n  orphan study records (likely historical or pre-OFT records)\n- **0 vitamin dossiers** have animal health studies — vitamin\n  studies follow a separate FLEX_REC / LIT pathway; this dataset\n  is exclusively for feed-additive and pesticide-substance\n  toxicology.\n\n## Test species distribution (n=382)\n\n| Species | Count | % |\n|---------|------:|--:|\n| \"other:\" (placeholder) | 191 | 50.0% |\n| swine (pigs) | 99 | 25.9% |\n| horse | 33 | 8.6% |\n| turkey | 26 | 6.8% |\n| sheep | 23 | 6.0% |\n| goat | 4 | 1.0% |\n| rabbit | 4 | 1.0% |\n| cow | 2 | 0.5% |\n\n**No dogs or cats explicitly tagged** — though the \"other:\"\nplaceholder may cover pet studies (subject to follow-up check\non species.Other free-text field).\n\n## Sex distribution (n=155 where reported)\n\n| Sex | Count |\n|-----|------:|\n| male/female (mixed) | 76 |\n| male | 64 |\n| female | 15 |\n\n227 records did not report sex.\n\n## Route of exposure (n=325 where reported)\n\n| Route | Count |\n|-------|------:|\n| \"other:\" (placeholder) | 276 |\n| oral: applied on feed | 34 |\n| oral: unspecified | 11 |\n| oral: gavage | 3 |\n| oral: capsule | 1 |\n\n**95% of studies use oral exposure** — consistent with feed\nadditive toxicology (animals ingest the substance via feed).\nOnly ~5% are explicitly labelled; the \"other:\" category covers\nthe rest and likely includes most oral feed studies.\n\n## Duration of treatment (n=293 where reported)\n\n| Unit | Count |\n|------|------:|\n| days (d) | 215 |\n| weeks (wk) | 78 |\n\nSample durations observed: 3 to 36 days, 12-21 weeks common.\n**Subacute to subchronic range** — typical for feed additive\nregistration studies (90-day dog studies, 28-day rodent\nstudies).\n\n## GLP compliance (n=382)\n\n| Status | Count |\n|--------|------:|\n| \"not specified\" | 362 |\n| \"yes\" | 13 |\n| \"no\" | 7 |\n\n**95% \"not specified\"** — these studies predate EFSA's\ncurrent GLP requirements or come from older registrations\nwhere GLP compliance was not strictly logged.\n\n## Dose levels\n\n| Field | Note |\n|-------|------|\n| `DoseConc.Value` | **None for 358/382 records** — dose values not consistently captured |\n| `DoseConc.Unit` | \"other:\" (18), \"mg/kg diet\" (6) |\n\nDose values are sparsely populated in this dataset, making\nit unsuitable for direct quantitative dose-response\nanalysis. The **effect level values** are more useful\n(see below).\n\n## Effect levels (n=382)\n\n| Field | Distribution |\n|-------|--------------|\n| `EffectLevel.lowerValue` | ranges from 2 to 450 (numeric observations) |\n| `EffectLevel.Unit` | \"other:\" (377), \"mg/kg diet\" (5) |\n| `Basis` | \"other:\" (most), \"clinical biochemistry\", \"body weight and weight gain\", \"food consumption and compound intake\" |\n\n`Basis` records indicate **why the effect level was set**:\n- 4 records on clinical biochemistry\n- 1+ records on body weight and weight gain\n- 1+ records on food consumption and compound intake\n- Most fall into \"other:\" placeholder\n\n## Target organ / system toxicity (n=18 where reported)\n\n| Organ | Count | System |\n|-------|------:|--------|\n| kidney | 6 | urinary |\n| liver | 6 | hepatobiliary |\n| intestine | 4 | gastrointestinal tract |\n| spleen | 1 | immune system |\n| heart | 1 | cardiovascular |\n\n**364 records have no target organ reported** — effect\nlevels are stated but without organ-system attribution.\nThis is typical of older studies or summarised endpoint\nrecords.\n\n## Pet food relevance\n\nThis is **the only experimental sheet in OpenFoodTox 3.0\nexplicitly mentioning \"and pets\" in its endpoint label**.\nThe other endpoint sheets (HumanHealth, TerrestEcotox,\nAquaticEcotox) deal with non-pet species or human safety.\n\nThe 191 \"other:\" species placeholders warrant follow-up\ninvestigation of the species.Other free-text field —\nif even 10-20% of those are dogs/cats, this dataset\nwould contain 20-40 direct pet toxicology studies.\n\nThe 131 distinct parent dossiers represent the\n**131 feed-additive / pesticide substances** with\npeer-reviewed or industry-submitted animal toxicology\ndata registered in the EU system.\n\n## Gaps & follow-up\n\n- **species.Other field not parsed** in this scan; the\n  191 \"other:\" placeholders may contain specific pet\n  or livestock species designations worth extracting.\n- **dose_value missing for 358/382** records — quantitative\n  dose-response analysis impossible without further join\n  with FLEX_SUM.ToxRefValues (which may have dose fields).\n- **82 records have no parent dossier** — likely historical\n  or open-data orphan records.\n\n## Related topics\n\n- `EFSA_OpenFoodTox_3_animal_health_study_records` —\n  earlier topic; this deep slice supersedes it\n- `EFSA_OpenFoodTox_3_toxref_values_distribution` —\n  ToxRef values distribution (different sheet, may have\n  dose values)\n\n## Source\n\n`toxicology/efsa/OFT3.0_export_repository.xlsx` sheet\n`END_STUDY_REC.AnimalHealth`. All 382 rows scanned;\ndistribution statistics computed via openpyxl read-only\nmode. Verified 2026-07-20.","sources":[],"tokens_estimated":540,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}