EFSA FEEDAP — L-isoleucine (C. glutamicum CCTCC M 2022764) for all animal species
Source: EFSA FEEDAP scientific opinion, EFSA Journal 2026;24(2):e9923 (DOI 10.2903/j.efsa.2026.9923), retrieved 2026-08-06 via Europe PMC OA full-text XML. Paraphrase of an EFSA opinion that the source XML tags CC-BY-ND; per project COPYRIGHT_POLICY only facts/numbers/proper-nouns are quoted verbatim, sentences rewritten.
Editorial context (read this before using the data point)
This is the EFSA FEEDAP jurisdiction on the nutrient/additive L-isoleucine (C. glutamicum CCTCC M 2022764) — one of five nutrient-safety opinions in this final batch (Task L). Read with the efsa nutrient endpoints and AAFCO/FEDIAF provisions for the same nutrient.
Key findings (paraphrase; numbers and proper nouns verbatim from source)
- The additive is safe for the target species when supplemented in appropriate amounts to the diet according to nutritional needs (fermentation with *C. glutamicum* CCTCC M 2022764).
- The Panel has concerns on L-isoleucine in drinking water.
- It is safe for the consumer and for the environment; in the absence of data the Panel cannot conclude on skin/eye irritancy or dermal sensitisation.
- It is an effective source of L-isoleucine for all non-ruminant species; ruminants need protection from ruminal degradation.
Pet-food relevance
L-isoleucine is an essential branched-chain amino acid in cats and dogs. The 'safe when supplemented to nutritional need' conclusion plus the drinking-water caveat are the usable formulator takeaways.
Scope note / honest gap
Paraphrase of an EFSA opinion; source XML licence tag was CC-BY-ND, so this topic quotes only data points verbatim and rewrites prose. Full strain-characterisation and tolerance statistics are not reproduced.