{"topic_id":"EFSA_FEEDAP_lisoleucine_safety","category":"efsa","context":"---\ntopic_id: EFSA_FEEDAP_lisoleucine_safety\ncategory: efsa\ntitle: \"EFSA FEEDAP — L-isoleucine (C. glutamicum CCTCC M 2022764) for all animal species: safe when supplemented; drinking-water concerns (EFSA Journal 2026;24(2):e9923)\"\nlang: en\nsource: \"EFSA FEEDAP scientific opinion, EFSA Journal 2026;24(2):e9923 (DOI 10.2903/j.efsa.2026.9923)\"\nsource_file: pdf-raw/efsa_l/isoleucine_b6.xml\nsource_type: journal_article\ndate_parsed: 2026-08-06\ntokens_estimated: 460\nverified: true\nverification:\n  method: paraphrase\n  claims: 5\n  passed: 5\n  date: 2026-08-06\nsource_document: \"EFSA FEEDAP — L-isoleucine (C. glutamicum CCTCC M 2022764) for all animal species: safe when supplemented; drinking-water concerns (EFSA Journal 2026;24(2):e9923)\"\ncitation:\n  authority: \"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)\"\n  title: \"EFSA FEEDAP — L-isoleucine (C. glutamicum CCTCC M 2022764) for all animal species: safe when supplemented; drinking-water concerns (EFSA Journal 2026;24(2):e9923)\"\n  url: \"https://doi.org/10.2903/j.efsa.2026.9923\"\n  retrieved: \"2026-08-06\"\n  ref: \"EFSA Journal 2026;24(2):e9923\"\n  doc_type: \"EFSA scientific opinion (Europe PMC OA full-text XML)\"\n  needs_review: false\nauthority_tier: T1\nauthority_tier_basis: \"T1:eu-body\"\nauthority_tier_date: 2026-08-06\n---\n# EFSA FEEDAP — L-isoleucine (C. glutamicum CCTCC M 2022764) for all animal species\n\nSource: EFSA FEEDAP scientific opinion, EFSA Journal 2026;24(2):e9923 (DOI 10.2903/j.efsa.2026.9923), retrieved 2026-08-06 via Europe PMC OA full-text XML. Paraphrase of an EFSA opinion that the source XML tags CC-BY-ND; per project COPYRIGHT_POLICY only facts/numbers/proper-nouns are quoted verbatim, sentences rewritten.\n\n## Editorial context (read this before using the data point)\n\nThis is the **EFSA FEEDAP** jurisdiction on the nutrient/additive **L-isoleucine (C. glutamicum CCTCC M 2022764)** — one of five nutrient-safety opinions in this final batch (Task L). Read with the `efsa` nutrient endpoints and AAFCO/FEDIAF provisions for the same nutrient.\n\n## Key findings (paraphrase; numbers and proper nouns verbatim from source)\n\n- The additive is **safe for the target species when supplemented in appropriate amounts to the diet according to nutritional needs** (fermentation with *C. glutamicum* CCTCC M 2022764).\n- The Panel has **concerns on L-isoleucine in drinking water**.\n- It is **safe for the consumer and for the environment**; in the absence of data the Panel **cannot conclude** on skin/eye irritancy or dermal sensitisation.\n- It is an **effective source of L-isoleucine for all non-ruminant species**; ruminants need protection from ruminal degradation.\n\n## Pet-food relevance\n\nL-isoleucine is an essential branched-chain amino acid in cats and dogs. The 'safe when supplemented to nutritional need' conclusion plus the drinking-water caveat are the usable formulator takeaways.\n\n## Scope note / honest gap\n\nParaphrase of an EFSA opinion; source XML licence tag was CC-BY-ND, so this topic quotes only data points verbatim and rewrites prose. Full strain-characterisation and tolerance statistics are not reproduced.\n","sources":["OFT3 — EFSA FEEDAP — L-isoleucine (C. glutamicum CCTCC M 2022764) for all animal species: safe when supplemented; drinking-water concerns (EFSA Journal 2026;24(2):e9923) (retrieved 2026-08-06)"],"source":{"authority":"OFT3","title":"EFSA FEEDAP — L-isoleucine (C. glutamicum CCTCC M 2022764) for all animal species: safe when supplemented; drinking-water concerns (EFSA Journal 2026;24(2):e9923)","url":"https://doi.org/10.2903/j.efsa.2026.9923","retrieved":"2026-08-06","ref":"","doc_type":"official PDF","source_document":"EFSA FEEDAP — L-isoleucine (C. glutamicum CCTCC M 2022764) for all animal species: safe when supplemented; drinking-water concerns (EFSA Journal 2026;24(2):e9923)","verification_file":"pdf-raw/efsa_l/isoleucine_b6.xml"},"source_document":"EFSA FEEDAP — L-isoleucine (C. glutamicum CCTCC M 2022764) for all animal species: safe when supplemented; drinking-water concerns (EFSA Journal 2026;24(2):e9923)","source_file":"pdf-raw/efsa_l/isoleucine_b6.xml","trust":{"authority_tier":"T1","fidelity":"paraphrase","license":null,"display_grade":"C"},"tokens_estimated":440,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}