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EFSA FEEDAP — copper(II)-betaine complex for all animal species: safe if max EU copper not exceeded; nickel makes it skin & respiratory sensitiser, eye irritant (EFSA Journal 2023;21(2):e07817)

EFSA_FEEDAP_copper_betaine_safety

efsa 470 tok en 2026-08-06

EFSA FEEDAP — copper(II)-betaine complex for all animal species

Source: EFSA FEEDAP scientific opinion, EFSA Journal 2023;21(2):e07817 (DOI 10.2903/j.efsa.2023.7817), retrieved 2026-08-06 via Europe PMC OA full-text XML. Paraphrase of an EFSA opinion that the source XML tags CC-BY-ND; per project COPYRIGHT_POLICY only facts/numbers/proper-nouns are quoted verbatim, sentences rewritten.

Editorial context (read this before using the data point)

This is the EFSA FEEDAP jurisdiction on the nutrient/additive copper(II)-betaine complex (trace element, copper source) — one of five nutrient-safety opinions in this final batch (Task L). Read with the efsa nutrient endpoints and AAFCO/FEDIAF provisions for the same nutrient.

Key findings (paraphrase; numbers and proper nouns verbatim from source)

  • A tolerance study shows the additive is safe for chickens for fattening; this extrapolates to all animal species provided the EU maximum authorised total-copper levels in feed are not exceeded.
  • Consumer safety: no concern provided max authorised total copper levels are respected.
  • User safety — key caveat: owing to the presence of nickel, the additive is a skin and respiratory sensitiser and an eye irritant (but non-irritant to skin).
  • Environment: safe for terrestrial species and land-based aquaculture; no conclusion for marine sediment safety in sea cages.
  • Efficacy cannot be demonstrated from the available data.

Pet-food relevance

A copper source for pet (and livestock/aquaculture) diets. The binding constraint is the EU maximum total-copper level; the nickel-driven sensitiser/eye-irritant warning is the practical handling note. Directly cross-references the efsa trace-element/copper endpoints.

Scope note / honest gap

Paraphrase of an EFSA opinion; source XML licence tag was CC-BY-ND, so this topic quotes only data points verbatim and rewrites prose. Specific EU max copper ppm values are not quoted (they sit in the authorisation, not the conclusion text); consult the EU register for exact numbers.

Sources

EFSA FEEDAP — copper(II)-betaine complex for all animal species: safe if max EU copper not exceeded; nickel makes it skin & respiratory sensitiser, eye irritant (EFSA Journal 2023;21(2):e07817)
Source document: EFSA FEEDAP — copper(II)-betaine complex for all animal species: safe if max EU copper not exceeded; nickel makes it skin & respiratory sensitiser, eye irritant (EFSA Journal 2023;21(2):e07817)
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)EFSA Journal 2023;21(2):e07817retrieved 2026-08-06

Verification file: pdf-raw/efsa_l/copperbetaine_b6.xml