EFSA FEEDAP — 25-hydroxycholecalciferol feed additive
Source: EFSA FEEDAP scientific opinion, EFSA Journal 2023;21(7):8168 (DOI 10.2903/j.efsa.2023.8168), retrieved 2026-08-06 via Europe PMC OA full-text XML. Paraphrase of an EFSA opinion that the source XML tags CC-BY-ND; per project COPYRIGHT_POLICY only facts/numbers/proper-nouns are quoted verbatim, sentences rewritten.
Editorial context (read this before using the data point)
This is the EFSA FEEDAP jurisdiction on 25-hydroxycholecalciferol — a vitamin-D-source feed additive (a more potent vitamin D3 metabolite) used in pet and animal nutrition. Read with EFSA_NDA_vitamin_D_UL and the efsa vitamin-D endpoints.
Key findings (paraphrase; numbers and proper nouns verbatim from source)
- The Panel concluded that 25-hydroxycholecalciferol remains safe for the target species, the consumer and the environment under the existing conditions of the authorisation.
- The additive is not irritant to the skin or eyes; however, no conclusion on its potential to be a skin sensitiser or on its effects on the respiratory system could be reached due to absence of data.
- The production strain qualifies for the QPS approach to safety assessment and the genetic modifications are of no concern for the toxicological profile.
Pet-food relevance
25-hydroxycholecalciferol is a common vitamin-D source in pet foods; its retained safety under authorisation and the skin/eye-irritation caveats are the decision-relevant points.
Scope note / honest gap
Paraphrase of an EFSA opinion; full study detail is not reproduced. Source XML licence tag was CC-BY-ND, so this topic quotes only data points verbatim and rewrites prose.