{"topic_id":"EFSA_FEEDAP_25hydroxycholecalciferol","category":"efsa","context":"---\ntopic_id: EFSA_FEEDAP_25hydroxycholecalciferol\ncategory: efsa\ntitle: \"EFSA FEEDAP — 25-hydroxycholecalciferol (vitamin D3 metabolite) feed additive remains safe under existing authorisation (EFSA Journal 2023;21(7):8168)\"\nlang: en\nsource: \"EFSA scientific opinion, EFSA Journal 2023;21(7):8168 (DOI 10.2903/j.efsa.2023.8168)\"\nsource_file: pdf-raw/efsa_l/PMC10410499.xml\nsource_type: journal_article\ndate_parsed: 2026-08-06\ntokens_estimated: 430\nverified: true\nverification:\n  method: paraphrase\n  claims: 4\n  passed: 4\n  date: 2026-08-06\nsource_document: \"EFSA Journal 21(7):8168 — EFSA FEEDAP — 25-hydroxycholecalciferol (vitamin D3 metabolite) feed additive remains safe under existing authorisation (EFSA Journal 2023;21(7):8168)\"\ncitation:\n  authority: \"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)\"\n  title: \"EFSA FEEDAP — 25-hydroxycholecalciferol (vitamin D3 metabolite) feed additive remains safe under existing authorisation (EFSA Journal 2023;21(7):8168)\"\n  url: \"https://doi.org/10.2903/j.efsa.2023.8168\"\n  retrieved: \"2026-08-06\"\n  ref: \"EFSA Journal 2023;21(7):8168\"\n  doc_type: \"EFSA scientific opinion (Europe PMC OA full-text XML)\"\n  needs_review: false\nauthority_tier: T1\nauthority_tier_basis: \"T1:eu-body\"\nauthority_tier_date: 2026-08-06\n---\n# EFSA FEEDAP — 25-hydroxycholecalciferol feed additive\n\nSource: EFSA FEEDAP scientific opinion, EFSA Journal 2023;21(7):8168 (DOI 10.2903/j.efsa.2023.8168), retrieved 2026-08-06 via Europe PMC OA full-text XML. Paraphrase of an EFSA opinion that the source XML tags CC-BY-ND; per project COPYRIGHT_POLICY only facts/numbers/proper-nouns are quoted verbatim, sentences rewritten.\n\n## Editorial context (read this before using the data point)\n\nThis is the **EFSA FEEDAP** jurisdiction on **25-hydroxycholecalciferol** — a vitamin-D-source feed additive (a more potent vitamin D3 metabolite) used in pet and animal nutrition. Read with `EFSA_NDA_vitamin_D_UL` and the `efsa` vitamin-D endpoints.\n\n## Key findings (paraphrase; numbers and proper nouns verbatim from source)\n\n- The Panel concluded that **25-hydroxycholecalciferol remains safe for the target species, the consumer and the environment under the existing conditions of the authorisation**.\n- The **additive is not irritant to the skin or eyes**; however, **no conclusion on its potential to be a skin sensitiser or on its effects on the respiratory system** could be reached due to absence of data.\n- The **production strain qualifies for the QPS approach** to safety assessment and the genetic modifications are of no concern for the toxicological profile.\n\n## Pet-food relevance\n\n25-hydroxycholecalciferol is a common vitamin-D source in pet foods; its retained safety under authorisation and the skin/eye-irritation caveats are the decision-relevant points.\n\n## Scope note / honest gap\n\nParaphrase of an EFSA opinion; full study detail is not reproduced. Source XML licence tag was CC-BY-ND, so this topic quotes only data points verbatim and rewrites prose.\n","sources":["OFT3 — EFSA FEEDAP — 25-hydroxycholecalciferol (vitamin D3 metabolite) feed additive remains safe under existing authorisation (EFSA Journal 2023;21(7):8168) (retrieved 2026-08-06)"],"source":{"authority":"OFT3","title":"EFSA FEEDAP — 25-hydroxycholecalciferol (vitamin D3 metabolite) feed additive remains safe under existing authorisation (EFSA Journal 2023;21(7):8168)","url":"https://doi.org/10.2903/j.efsa.2023.8168","retrieved":"2026-08-06","ref":"","doc_type":"official PDF","source_document":"EFSA Journal 21(7):8168 — EFSA FEEDAP — 25-hydroxycholecalciferol (vitamin D3 metabolite) feed additive remains safe under existing authorisation (EFSA Journal 2023;21(7):8168)","verification_file":"pdf-raw/efsa_l/PMC10410499.xml"},"source_document":"EFSA Journal 21(7):8168 — EFSA FEEDAP — 25-hydroxycholecalciferol (vitamin D3 metabolite) feed additive remains safe under existing authorisation (EFSA Journal 2023;21(7):8168)","source_file":"pdf-raw/efsa_l/PMC10410499.xml","trust":{"authority_tier":"T1","fidelity":"paraphrase","license":null,"display_grade":"C"},"tokens_estimated":360,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}