EN — For pet owners. Afoxolaner, fluralaner, sarolaner and lotilaner are all isoxazoline-class agents — the four common flea-and-tick pills/chews. They work the same way: they block insect and acarine GABA- and glutamate-gated chloride channels, killing fleas and ticks. Their US FDA adverse-event report totals differ hugely: Fluralaner: 88486, Sarolaner: 79692, Afoxolaner: 69037, Lotilaner: 13432. The source notes Seizure NOS appears in every brother — a class-wide neurological signal in the reports. Two cautions: *"Lack of efficacy"* terms denote product-performance reports (the product didn't kill the parasite) and must not be read as toxicity; and reported ≠ causal. Bottom line — report counts differ mostly with exposure breadth; a filed report is not proof of harm.
中文 — 给宠物主人。 Afoxolaner, fluralaner, sarolaner and lotilaner are all isoxazoline-class agents——四种常见异噁唑啉类驱虫药。作用机制相同：they block insect and acarine GABA- and glutamate-gated chloride channels, killing fleas and ticks.（阻断跳蚤蜱虫的氯离子通道将其杀死。）四者在美国 FDA 不良事件报告总数差别很大：Fluralaner: 88486、Sarolaner: 79692、Afoxolaner: 69037、Lotilaner: 13432。源文指出 Seizure NOS appears in every brother（四种的报告里都出现癫痫条目，是全类共有的神经学信号）。两点注意：*"Lack of efficacy"* terms denote product-performance reports (the product didn't kill the parasite)（"无效"类术语是产品性能报告，不能当成毒性）；且 reported ≠ causal（有报告 ≠ 有因果）。结论——报告数量差异主要反映使用面广度；有报告不等于证明有害。
Source article: isoxazoline-four-brothers-ade (built from C1-verified openFDA source topics).
Claims (verified as substrings of the C1-verified source article)
Afoxolaner, fluralaner, sarolaner and lotilaner are all isoxazoline-class agentsthey block insect and acarine GABA- and glutamate-gated chloride channels, killing fleas and ticks.Fluralaner: 88486Sarolaner: 79692Afoxolaner: 69037Lotilaner: 13432Seizure NOS appears in every brother*"Lack of efficacy"* terms denote product-performance reports (the product didn't kill the parasite)reported ≠ causal