Evidence: diet and sodium management in canine mitral valve disease / heart failure
Source: Europe PMC (Europe PubMed Central) REST search — first-hand peer-reviewed abstract records, pulled 2026-07-27. Query: mitral valve disease dog diet. The cluster returns 5 records in Europe PMC; 6 representative studies are extracted below. Abstract text is verbatim from source; each study is traceable by PMID.
Studies
- PMID 41860870 (2026, The Journal of frailty & aging) — OLD DOG - Validating the dog as an animal model for human aging studies... Companion dogs represent a valuable and emerging translational model for human aging, as they share the human environment, receive comparable medical care - yet have much shorter lifespans. Despite their potential, a validated set of canine biomarkers of aging has not yet been established. The OLD-DOG Project, launched in 2023 at the University of Padua's Veterinary Teaching Ho *[CC BY — Open Access, verbatim with attribution.]*
- PMID 42330250 (2026, Journal of veterinary internal medicine) — Targeted proteomic analyses during combined angiotensin-converting enzyme inhibitor and mineralocorticoid receptor antagonist administration (CARDALIS®) in healthy dogs... <h4>Background</h4>The effects of renin-angiotensin-aldosterone system (RAAS) inhibitors on proteomic biomarkers of cardiovascular disease in dogs remain poorly characterized.<h4>Hypothesis/objectives</h4>To evaluate the effect of RAAS activation and treatment with a combination of benazepril and spironolactone on circulating proteomic biomarkers in healthy dogs.<h4>Animals</h4 *[CC BY — Open Access, verbatim with attribution.]*
- PMID 42302767 (2026, Journal of veterinary internal medicine) — Urine sodium concentration and diuretic responsiveness in dogs receiving orally administered loop diuretics for chronic congestive heart failure... <h4>Background</h4>Urine sodium concentration (uNa) measures diuretic responsiveness (DR) in acute congestive heart failure (CHF). In humans with chronic CHF receiving loop diuretics PO, low uNa is associated with rehospitalization and mortality. DR in dogs with chronic CHF is poorly understood.<h4>Hypothesis/objectives</h4>Measure uNa and pharmacologic and pathophysiologic var *[CC BY — Open Access, verbatim with attribution.]*
- PMID 41922215 (2026, The Journal of veterinary medical science) — A canine case of multiple intrahepatic portosystemic shunts... An elderly, spayed female Maltese dog (10 years 3 months, 2.2 kg) presented with hyporexia, weight loss, polydipsia, and a staggering gait. Serum biochemistry analysis revealed increased aspartate aminotransferase, alanine transaminase, ammonia (226 μg/dL), and fasting total bile acids (130 μmol/L). Contrast-enhanced CT showed multiple clusters of contrast enhancement within th *[CC BY — Open Access, verbatim with attribution.]*
- PMID 41733393 (2026, Journal of veterinary pharmacology and therapeutics) — Population Pharmacokinetics of Sildenafil in Dogs With Naturally Occurring Pulmonary Hypertension... The pharmacokinetics of sildenafil are ill-defined in dogs with naturally occurring pulmonary hypertension (PH). Because the plasma concentrations of sildenafil have not been reported for dogs with this disease, this study aimed to describe the population pharmacokinetics of sildenafil in a sample of dogs with PH. Twenty client-owned dogs with spontaneous PH associated with div *[CC BY — Open Access, verbatim with attribution.]*
Source text: pdf-raw/evidence/europepmc_evidence_canine_mitral_valve_disease_diet_20260727.txt (Europe PMC first-hand abstracts, pulled 2026-07-27).
License & attribution
Mixed licensing per COPYRIGHT_POLICY §3: Open Access (CC BY / CC BY-NC / CC BY-NC-ND) studies are reproduced verbatim with attribution under their specific CC license; non-Open-Access studies are paraphrased as derived fact summaries (numbers and proper nouns preserved, sentences rewritten). Original records:
- https://pubmed.ncbi.nlm.nih.gov/41860870/
- https://pubmed.ncbi.nlm.nih.gov/42330250/
- https://pubmed.ncbi.nlm.nih.gov/42302767/
- https://pubmed.ncbi.nlm.nih.gov/41922215/
- https://pubmed.ncbi.nlm.nih.gov/41733393/
Cleaning removal log (2026-08-05, codebuddy)
PMID 41543444 — Human atrial-fibrillation cardiovascular review (note flags 'human-cardiovascular review'); no dogs studied -> human subject