--- license: permission_granted topic_id: companion_species_health_tremor_x_linked_rabbit category: companion-species-health title: "Rabbit (Oryctolagus cuniculus) — Tremor, X-linked (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/rabbit_tremor_x_linked_12.txt date_parsed: 2026-08-24 tokens_estimated: 80 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_tremor_x_linked_rabbit/01_companion_species_health_tremor_x_linked_rabbit.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Rabbit (Oryctolagus cuniculus) — Tremor, X-linked (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA000770/9986/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Rabbit (Oryctolagus cuniculus) — Tremor, X-linked (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Rabbit (Oryctolagus cuniculus)Disorder: Tremor, X-linkedSummary: This is an X-linked disorder that affects myelination of the central nervous system.
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: PLP (Entrez Gene ID 4118891) — OMIA Phene_Gene / GeneSynonym
- OMIA molecular-genetics note: Building on the results of Tosic et al. (1993) that this disorder is primarily due to faulty expression of the proteolipid protein (PLP) gene, Tosic et al. (1994) sequenced PLP cDNA from normal and affected rabbits and showed that the disorder is due to a point mutation in exon 2 of the PLP gene, corresponding to the end of the first potential transmembrane domain of the protein. The mutation remo…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1993. Paralytic Tremor (pt) Rabbit - A Sex-Linked Mutation Affecting Proteolipid Protein-Gene Expression. Brain Research — PubMed:PMID8275312 — OMIA Phene_Article / Article
- 1994. Paralytic tremor (pt): A new allele of the proteolipid protein gene in rabbits. Journal of Neurochemistry — PubMed:PMID7525875 — OMIA Phene_Article / Article
- 2005. Rabbit paralytic tremor phenotype--a plp1 gene mutation as a model of human Pelizaeus-Merzbacher disease. Acta Neurobiol Exp (Wars) — PubMed:PMID15960310 — OMIA Phene_Article / Article
- 1995. Oligodendrocyte development in PLP "pt" mutant rabbits: glycolipid antigens and PLP gene expression. Metab Brain Dis — PubMed:PMID8847995 — OMIA Phene_Article / Article
- 1995. Expression of myelin-specific proteins during development of normal and hypomyelinated Paralytic tremor mutant rabbits. II. Studies on the purified myelin. Mol Chem Neuropathol — PubMed:PMID8588825 | DOI:10.1007/BF02814942 — OMIA Phene_Article / Article
- 1995. Expression of myelin-specific proteins during development of normal and hypomyelinated Paralytic tremor mutant rabbits. I. Studies on the brain homogenates. Mol Chem Neuropathol — PubMed:PMID8588824 | DOI:10.1007/BF02814941 — OMIA Phene_Article / Article
- 1988. Myelin composition and activities of CNPase and Na+,K+-ATPase in hypomyelinated "pt" mutant rabbit. J Neurochem — PubMed:PMID2826682 — OMIA Phene_Article / Article
- 1996. pt point mutation in plp gene results in hyperexpression of MOG in hypomyelinated rabbit. Acta Neurobiol Exp (Wars) — PubMed:PMID8787215 — OMIA Phene_Article / Article
- 1997. Intracellular transport of the DM-20 bearing shaking pup (shp) mutation and its possible phenotypic consequences. J Neurosci Res — PubMed:PMID9418971 | DOI:10.1002/(SICI)1097-4547(19971201)50:5<844::AID-JNR20>3.0.CO;2-# — OMIA Phene_Article / Article
- 1937. Erbpathologische Untersuchungen am Kaninchen [Investigation of inherited defects in rabbits]. Z. indo Abst. u. Vererbgs — DOI:10.1007/BF01847500 — OMIA Phene_Article / Article
- 1976. Elektronenmikroskopische Untersuchung der intrazerebralen Verkalkungen bei dem erblichen paralytischen Tremor der pt-Kaninchen [Electron microscopic studies of intracerebral calcifications in hereditary paralytic tremor in pt rabbits]. Neuropatol Pol — PubMed:PMID967309 — OMIA Phene_Article / Article
- 1986. Brain lipids of a myelin-deficient rabbit mutant during development. Neurochem Pathol — PubMed:PMID3561890 | DOI:10.1007/BF02834354 — OMIA Phene_Article / Article
- (13 additional references in OMIA)
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:312080 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:300401 (type: gene) — OMIA Group_OMIM (via OMIA_ID)