← All Topics / companion-species-health

Dog (Canis lupus familiaris) — Thrombocytopenia (hereditary; OMIA-verified species predisposition)

companion_species_health_thrombocytopenia_dog

companion-species-health en

--- license: permission_granted topic_id: companion_species_health_thrombocytopenia_dog category: companion-species-health title: "Dog (Canis lupus familiaris) — Thrombocytopenia (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/dog_thrombocytopenia_1729.txt date_parsed: 2026-08-24 tokens_estimated: 441 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_thrombocytopenia_dog/01_companion_species_health_thrombocytopenia_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dog (Canis lupus familiaris) — Thrombocytopenia (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001001/9615/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose." verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Dog (Canis lupus familiaris) — Thrombocytopenia (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Species: Dog (Canis lupus familiaris)
  • Disorder: Thrombocytopenia
  • Summary: See OMIA 002434-9615 : Thrombocytopenia, TUBB1-related in Canis lupus familiaris for this disease in Cavalier King Charles Spaniels and Norfolk and Cairn Terriers
  • Clin feat: This disorder occurs in many different forms, many of which are not inherited. As summarised by Żmigrodzka et al. (2014), "Thrombocytopenia (low platelet count) can occur as a result of a megacaryocyte disorder, disturbance of platelet production as well as their premature destruction. Platelet count can be also decreased due to sequestration of platelets in the tissues . . . . Myeloproliferative bone marrow disorders as well as certain drugs (e.g. oestrogens and chloramphenicol) can alter platelet production in the bone marrow . . . . The most frequent cause of thrombocytopenia is premature platelet destruction due to an abnormal immune response; when no underlying disease is found and aetiological agent remains undetermined IMT is described as primary. Secondary disease can develop in neoplastic conditions (e.g. mammary gland tumour, haemangiosarcoma, and lymphoma), infectious diseases (e.g. babesiosis, leptospirosis, and other bacterial, viral, and parasitic infections), after vaccination with live attenuated viruses (e.g. canine distemper virus), or after drug treatment (e.g. chloramphenicol, cephalosporin, sulphonamides, and gold salts). Rapid platelet consumption is often observed in acute haemorrhage, disseminated intravascular coagulation, or inflammation. Destruction and consumption of platelets are also enhanced in microangiopathies . . . . Common causes of platelet sequestration are splenomegaly, splenic torsion, and sepsis . . . ."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1994. Comparison of microscopic and flow cytometric detection of platelet antibody in dogs suspected of having immune-mediated thrombocytopenia. American Journal of Veterinary Research — PubMed:PMID7978651 — OMIA Phene_Article / Article
  • 1995. Canine immune-mediated thrombocytopenia .1. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article
  • 1995. Canine immune-mediated thrombocytopenia .3. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article
  • 1998. Sensitivity of resonance thrombography in thrombocytopenia in dogs [German]. Berliner und Munchener Tierarztliche Wochenschrift — PubMed:PMID9741188 — OMIA Phene_Article / Article
  • 2000. Thrombosis of the caudal vena cava presenting as an unusual cause of an abdominal mass and thrombocytopenia in a dog. Journal of the American Animal Hospital Association — PubMed:PMID10730625 — OMIA Phene_Article / Article
  • 2002. Comparison of platelet count recovery with use of vincristine and prednisone or prednisone alone for treatment for severe immune-mediated thrombocytopenia in dogs. Journal of the American Veterinary Medical Association — PubMed:PMID11860242 — OMIA Phene_Article / Article
  • 2005. Immune-mediated thrombocytopenia in a 4-month-old German shepherd dog. Can Vet J — PubMed:PMID16018567 — OMIA Phene_Article / Article
  • 2011. Asymptomatic macrothrombocytopenia in a young pure-bred beagle dog: a case report. Toxicol Pathol — PubMed:PMID21859886 | DOI:10.1177/0192623311416261 — OMIA Phene_Article / Article
  • 2004. Comparison of manual and automated methods for determining platelet counts in dogs with macrothrombocytopenia. J Vet Diagn Invest — PubMed:PMID15053372 — OMIA Phene_Article / Article
  • 2013. Erythrocyte dysplasia in peripheral blood smears from 5 thrombocytopenic dogs treated with vincristine sulfate. Vet Clin Pathol — PubMed:PMID24138476 | DOI:10.1111/vcp.12089 — OMIA Phene_Article / Article
  • 2014. Platelet volume and plateletcrit in dogs with presumed primary immune-mediated thrombocytopenia. J Vet Intern Med — PubMed:PMID25056453 | DOI:10.1111/jvim.12405 — OMIA Phene_Article / Article
  • 2014. Evaluation of reticulated platelets in dogs with breed-related thrombocytopenia. Pol J Vet Sci — PubMed:PMID24724481 | DOI:10.2478/pjvs-2014-0018 — OMIA Phene_Article / Article
  • (8 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:155100 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:141000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:188000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:188020 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:188025 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:188030 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:273900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:274000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:313900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613112 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1994. Comparison of microscopic and flow cytometric detection of platelet antibody in dogs suspected of having immune-mediated thrombocytopenia. American Journal of Veterinary Research — PubMed:PMID7978651 — OMIA Phene_Article / Article
  • 1995. Canine immune-mediated thrombocytopenia .1. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article
  • 1995. Canine immune-mediated thrombocytopenia .3. Compendium on Continuing Education for the Practicing Veterinarian — OMIA Phene_Article / Article
  • 1998. Sensitivity of resonance thrombography in thrombocytopenia in dogs [German]. Berliner und Munchener Tierarztliche Wochenschrift — PubMed:PMID9741188 — OMIA Phene_Article / Article
  • 2000. Thrombosis of the caudal vena cava presenting as an unusual cause of an abdominal mass and thrombocytopenia in a dog. Journal of the American Animal Hospital Association — PubMed:PMID10730625 — OMIA Phene_Article / Article
  • 2002. Comparison of platelet count recovery with use of vincristine and prednisone or prednisone alone for treatment for severe immune-mediated thrombocytopenia in dogs. Journal of the American Veterinary Medical Association — PubMed:PMID11860242 — OMIA Phene_Article / Article
  • 2005. Immune-mediated thrombocytopenia in a 4-month-old German shepherd dog. Can Vet J — PubMed:PMID16018567 — OMIA Phene_Article / Article
  • 2011. Asymptomatic macrothrombocytopenia in a young pure-bred beagle dog: a case report. Toxicol Pathol — PubMed:PMID21859886 | DOI:10.1177/0192623311416261 — OMIA Phene_Article / Article
  • 2004. Comparison of manual and automated methods for determining platelet counts in dogs with macrothrombocytopenia. J Vet Diagn Invest — PubMed:PMID15053372 — OMIA Phene_Article / Article
  • 2013. Erythrocyte dysplasia in peripheral blood smears from 5 thrombocytopenic dogs treated with vincristine sulfate. Vet Clin Pathol — PubMed:PMID24138476 | DOI:10.1111/vcp.12089 — OMIA Phene_Article / Article
  • 2014. Platelet volume and plateletcrit in dogs with presumed primary immune-mediated thrombocytopenia. J Vet Intern Med — PubMed:PMID25056453 | DOI:10.1111/jvim.12405 — OMIA Phene_Article / Article
  • 2014. Evaluation of reticulated platelets in dogs with breed-related thrombocytopenia. Pol J Vet Sci — PubMed:PMID24724481 | DOI:10.2478/pjvs-2014-0018 — OMIA Phene_Article / Article
  • (8 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:155100 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:141000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:188000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:188020 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:188025 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:188030 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:273900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:274000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:313900 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613112 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Sources

Dog (Canis lupus familiaris) — Thrombocytopenia (hereditary; OMIA-verified species predisposition)
companion-species-healthPMID 7978651

Machine access

AI agents: this page mirrors GET /api/v1/llm_context?topic=companion_species_health_thrombocytopenia_dog (max 500 tokens, whitelisted). Rate limit 60 req/min for recognized AI crawlers.

Raw JSON ↗ llm.txt OpenAPI