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Horse (Equus caballus) — Shivering (hereditary; OMIA-verified species predisposition)

companion_species_health_shivering_horse

companion-species-health en

--- license: permission_granted topic_id: companion_species_health_shivering_horse category: companion-species-health title: "Horse (Equus caballus) — Shivering (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/horse_shivering_1267.txt date_parsed: 2026-08-24 tokens_estimated: 139 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_shivering_horse/01_companion_species_health_shivering_horse.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Horse (Equus caballus) — Shivering (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA000676/9796/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose." verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Horse (Equus caballus) — Shivering (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Species: Horse (Equus caballus)
  • Disorder: Shivering
  • Summary: Valberg et al. (2023): "Shivers in horses is characterized by abnormal hindlimb movement when walking backward and is proposed to be caused by a Purkinje cell (PC) axonopathy based on histopathology. ... Differences in gene expression between Shivers and control horses were evident in principal component analysis of axon-containing white matter but not PC soma. ... Our findings support axonal degeneration as a characteristic feature of Shivers."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1999. Clinical and pathologic findings in two draft horses with progressive muscle atrophy, neuromuscular weakness, and abnormal gait characteristic of shivers syndrome. Journal of the American Veterinary Medical Association — PubMed:PMID14567431 — OMIA Phene_Article / Article
  • 1955. Lumbar lameness caused by inherited muscle atrophy inhorse. Journal of the Japanese Veterinary Medical Association — OMIA Phene_Article / Article
  • 2013. Genome-wide association analysis of Shivers in Belgian horses. Equine Genome Workshop, Plan and Animal Genome XXI, San Diego, CA — OMIA Phene_Article / Article
  • 2015. The equine movement disorder "Shivers" is associated with selective cerebellar Purkinje cell axonal degeneration. Vet Pathol — PubMed:PMID25714471 | DOI:10.1177/0300985815571668 — OMIA Phene_Article / Article
  • 2018. Abnormal locomotor muscle recruitment activity is present in horses with shivering and Purkinje cell distal axonopathy. Equine Vet J — PubMed:PMID29356055 | DOI:10.1111/evj.12813 — OMIA Phene_Article / Article
  • 2022. Shivering and Stringhalt in horses. Vet J — PubMed:PMID35462036 | DOI:10.1016/j.tvjl.2022.105829 — OMIA Phene_Article / Article
  • 2023. Cerebellar axonopathy in Shivers horses identified by spatial transcriptomic and proteomic analyses. J Vet Intern Med — PubMed:PMID37288990 | DOI:10.1111/jvim.16784 — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1999. Clinical and pathologic findings in two draft horses with progressive muscle atrophy, neuromuscular weakness, and abnormal gait characteristic of shivers syndrome. Journal of the American Veterinary Medical Association — PubMed:PMID14567431 — OMIA Phene_Article / Article
  • 1955. Lumbar lameness caused by inherited muscle atrophy inhorse. Journal of the Japanese Veterinary Medical Association — OMIA Phene_Article / Article
  • 2013. Genome-wide association analysis of Shivers in Belgian horses. Equine Genome Workshop, Plan and Animal Genome XXI, San Diego, CA — OMIA Phene_Article / Article
  • 2015. The equine movement disorder "Shivers" is associated with selective cerebellar Purkinje cell axonal degeneration. Vet Pathol — PubMed:PMID25714471 | DOI:10.1177/0300985815571668 — OMIA Phene_Article / Article
  • 2018. Abnormal locomotor muscle recruitment activity is present in horses with shivering and Purkinje cell distal axonopathy. Equine Vet J — PubMed:PMID29356055 | DOI:10.1111/evj.12813 — OMIA Phene_Article / Article
  • 2022. Shivering and Stringhalt in horses. Vet J — PubMed:PMID35462036 | DOI:10.1016/j.tvjl.2022.105829 — OMIA Phene_Article / Article
  • 2023. Cerebellar axonopathy in Shivers horses identified by spatial transcriptomic and proteomic analyses. J Vet Intern Med — PubMed:PMID37288990 | DOI:10.1111/jvim.16784 — OMIA Phene_Article / Article

Sources

Horse (Equus caballus) — Shivering (hereditary; OMIA-verified species predisposition)
companion-species-healthPMID 14567431

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