--- license: permission_granted topic_id: companion_species_health_retinal_atrophy_progressive_generic_dog category: companion-species-health title: "Dog (Canis lupus familiaris) — Retinal atrophy, progressive, generic (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/dog_retinal_atrophy_progressive_generic_1498.txt date_parsed: 2026-08-24 tokens_estimated: 143 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_retinal_atrophy_progressive_generic_dog/01_companion_species_health_retinal_atrophy_progressive_generic_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dog (Canis lupus familiaris) — Retinal atrophy, progressive, generic (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA000830/9615/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Dog (Canis lupus familiaris) — Retinal atrophy, progressive, generic (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Dog (Canis lupus familiaris)Disorder: Retinal atrophy, progressive, genericSummary: Many different forms of progressive retinal atrophy (PRA) exist and more than 10 different genes have been identified so far in dogs to have likely causal variants for PRA. Please review OMIA for other variants. Information relating to PRA due to a variant in the CNGB1 gene was previously listed here but has been moved to 'OMIA:002723-9615 : Retinal atrophy, progressive, CNGB1-related in Canis lupus familiaris' [16/06/2023].
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIA molecular-genetics note: Extensive molecular investigations have excluded the opsin gene as a candidate locus for this disorder in Miniature Poodles, English Cocker Spaniels or Labrador Retrievers (Gould et al., 1995).
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1969. The international sheep dog society and progressive retinal atrophy. Journal of Small Animal Practice — PubMed:PMID5816740 — OMIA Phene_Article / Article
- 1977. Hereditary eye abnormalities in the dog. II. Central progressive retinal atrophy. Animal Health Trust and Small Animal Centre — OMIA Phene_Article / Article
- 1965. Canine retinopathies. III. The other breeds. Journal of Small Animal Practice — OMIA Phene_Article / Article
- 1975. Progressive retinal atrophy in two atypical breeds of dogs. Veterinary Medicine and Small Animal Clinician — PubMed:PMID1043555 — OMIA Phene_Article / Article
- 1967. Three inherited ocular defects in the dog. Modern Veterinary Practice — OMIA Phene_Article / Article
- 1976. Inherited retinal degenerations in the dog. Transactions of the American Academy of Ophthalmology and Otology — OMIA Phene_Article / Article
- 1965. Canine retinopathies. II. The Miniature and Toy Poodle. Journal of Small Animal Practice — OMIA Phene_Article / Article
- 1965. Progressive retinal atrophy certification scheme. Veterinary Record — OMIA Phene_Article / Article
- 1980. Visual defects in dogs as the result of breed specific fundus diseases (progressive retinal atrophy and collie eye anomaly). Wiener Tierarztliche Monatsschrift — OMIA Phene_Article / Article
- 1965. Canine retinopathies. IV. Causes of retinal atrophy. Journal of Small Animal Practice — OMIA Phene_Article / Article
- 1990. Generalised Progressive Retinal Atrophy in the English Setter in Norway. Veterinary Record — PubMed:PMID2316162 — OMIA Phene_Article / Article
- 1986. [Progressive retinal atrophy (PRA) in Labrador Retrievers]. Svensk Veterinartidning — OMIA Phene_Article / Article
- (54 additional references in OMIA)