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Dog (Canis lupus familiaris) — Prostate cancer (hereditary; OMIA-verified species predisposition)

companion_species_health_prostate_cancer_dog

companion-species-health en

--- license: permission_granted topic_id: companion_species_health_prostate_cancer_dog category: companion-species-health title: "Dog (Canis lupus familiaris) — Prostate cancer (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/dog_prostate_cancer_4504.txt date_parsed: 2026-08-24 tokens_estimated: 244 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_prostate_cancer_dog/01_companion_species_health_prostate_cancer_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dog (Canis lupus familiaris) — Prostate cancer (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA002335/9615/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose." verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Dog (Canis lupus familiaris) — Prostate cancer (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Species: Dog (Canis lupus familiaris)
  • Disorder: Prostate cancer
  • Summary: Teske et al. (2002): "Prostate cancer is one of the most important malignancies in men in the Western world. ... The dog is one of the few other species in which spontaneous prostate cancer occurs." Teske et al. (2002) "investigated the frequency of prostate cancer among prostatic abnormalities in dogs and evaluated whether castration influences the incidence of prostate cancer in dogs. Other factors such as age at castration, age at diagnosis, and breed were included in an attempt to improve insight into the pathogenesis of prostate cancer in the dog .... We observed an increased risk of benign prostatic disease in the Scottish terrier, the Bouvier des Flandres, the Bernese mountain dog and the German Pointer. To our knowledge, a breed specificity for BPH, in Doberman Pinschers, has only been reported once before [Krawiec and Heflin, 1992]."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2019. Histopathological Terminology Standards for the Reporting of Prostatic Epithelial Lesions in Dogs. J Comp Pathol — PubMed:PMID31540623 | DOI:10.1016/j.jcpa.2019.07.005 — OMIA Phene_Article / Article
  • 2021. A comparative in silico analysis of CD24's prognostic value in human and canine prostate cancer. J Pers Med — PubMed:PMID33806857 | DOI:10.3390/jpm11030232 — OMIA Phene_Article / Article
  • 2018. Immunohistochemical panel to characterize canine prostate carcinomas according to aberrant p63 expression. PLoS One — PubMed:PMID29894516 | DOI:10.1371/journal.pone.0199173 — OMIA Phene_Article / Article
  • 2019. Characterization of OCT3/4, Nestin, NANOG, CD44 and CD24 as stem cell markers in canine prostate cancer. Int J Biochem Cell Biol — PubMed:PMID30633985 | DOI:10.1016/j.biocel.2019.01.002 — OMIA Phene_Article / Article
  • 2009. Prostate cancer in dogs: comparative and clinical aspects. Vet J — PubMed:PMID18786842 | DOI:10.1016/j.tvjl.2008.07.012 — OMIA Phene_Article / Article
  • 2002. Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs. Mol Cell Endocrinol — PubMed:PMID12431819 | DOI:10.1016/s0303-7207(02)00261-7 — OMIA Phene_Article / Article
  • 1992. Study of prostatic disease in dogs: 177 cases (1981-1986). J Am Vet Med Assoc — PubMed:PMID1376729 — OMIA Phene_Article / Article
  • 2022. Comparative pathology of dog and human prostate cancer. Vet Med Sci — PubMed:PMID34628719 | DOI:10.1002/vms3.642 — OMIA Phene_Article / Article
  • 2023. Comparative oncology: overcoming human cancer through companion animal studies. Exp Mol Med — PubMed:PMID37009802 | DOI:10.1038/s12276-023-00977-3 — OMIA Phene_Article / Article
  • 2023. Molecular similarities and differences between canine prostate cancer and human prostate cancer variants. Biomedicines — PubMed:PMID37189720 | DOI:10.3390/biomedicines11041100 — OMIA Phene_Article / Article
  • 2023. Pre-clinical models to study human prostate cancer. Cancers (Basel) — PubMed:PMID37686488 | DOI:10.3390/cancers15174212 — OMIA Phene_Article / Article
  • 2023. Orexins and prostate cancer: State of the art and potential experimental and therapeutic perspectives. Cancer Genomics Proteomics — PubMed:PMID38035703 | DOI:10.21873/cgp.20412 — OMIA Phene_Article / Article
  • (9 additional references in OMIA)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2019. Histopathological Terminology Standards for the Reporting of Prostatic Epithelial Lesions in Dogs. J Comp Pathol — PubMed:PMID31540623 | DOI:10.1016/j.jcpa.2019.07.005 — OMIA Phene_Article / Article
  • 2021. A comparative in silico analysis of CD24's prognostic value in human and canine prostate cancer. J Pers Med — PubMed:PMID33806857 | DOI:10.3390/jpm11030232 — OMIA Phene_Article / Article
  • 2018. Immunohistochemical panel to characterize canine prostate carcinomas according to aberrant p63 expression. PLoS One — PubMed:PMID29894516 | DOI:10.1371/journal.pone.0199173 — OMIA Phene_Article / Article
  • 2019. Characterization of OCT3/4, Nestin, NANOG, CD44 and CD24 as stem cell markers in canine prostate cancer. Int J Biochem Cell Biol — PubMed:PMID30633985 | DOI:10.1016/j.biocel.2019.01.002 — OMIA Phene_Article / Article
  • 2009. Prostate cancer in dogs: comparative and clinical aspects. Vet J — PubMed:PMID18786842 | DOI:10.1016/j.tvjl.2008.07.012 — OMIA Phene_Article / Article
  • 2002. Canine prostate carcinoma: epidemiological evidence of an increased risk in castrated dogs. Mol Cell Endocrinol — PubMed:PMID12431819 | DOI:10.1016/s0303-7207(02)00261-7 — OMIA Phene_Article / Article
  • 1992. Study of prostatic disease in dogs: 177 cases (1981-1986). J Am Vet Med Assoc — PubMed:PMID1376729 — OMIA Phene_Article / Article
  • 2022. Comparative pathology of dog and human prostate cancer. Vet Med Sci — PubMed:PMID34628719 | DOI:10.1002/vms3.642 — OMIA Phene_Article / Article
  • 2023. Comparative oncology: overcoming human cancer through companion animal studies. Exp Mol Med — PubMed:PMID37009802 | DOI:10.1038/s12276-023-00977-3 — OMIA Phene_Article / Article
  • 2023. Molecular similarities and differences between canine prostate cancer and human prostate cancer variants. Biomedicines — PubMed:PMID37189720 | DOI:10.3390/biomedicines11041100 — OMIA Phene_Article / Article
  • 2023. Pre-clinical models to study human prostate cancer. Cancers (Basel) — PubMed:PMID37686488 | DOI:10.3390/cancers15174212 — OMIA Phene_Article / Article
  • 2023. Orexins and prostate cancer: State of the art and potential experimental and therapeutic perspectives. Cancer Genomics Proteomics — PubMed:PMID38035703 | DOI:10.21873/cgp.20412 — OMIA Phene_Article / Article
  • (9 additional references in OMIA)

Sources

Dog (Canis lupus familiaris) — Prostate cancer (hereditary; OMIA-verified species predisposition)
companion-species-healthPMID 31540623

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