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Horse (Equus caballus) — Melanoma, generic (hereditary; OMIA-verified species predisposition)

companion_species_health_melanoma_generic_horse

companion-species-health en

--- license: permission_granted topic_id: companion_species_health_melanoma_generic_horse category: companion-species-health title: "Horse (Equus caballus) — Melanoma, generic (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/horse_melanoma_generic_4271.txt date_parsed: 2026-08-24 tokens_estimated: 80 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_melanoma_generic_horse/01_companion_species_health_melanoma_generic_horse.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Horse (Equus caballus) — Melanoma, generic (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA002231/9796/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Horse (Equus caballus) — Melanoma, generic (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Species: Horse (Equus caballus)
  • Disorder: Melanoma, generic
  • Summary: see also OMIA:001356-9796 : Coat colour, grey/gray in Equus caballus as gray horses have an increased risk of developing melanomas

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIA molecular-genetics note: Wong et al. (2019) performed "a cross-species analysis by sequencing tumor-germline pairs from 46 primary human muscosal, 65 primary canine oral and 28 primary equine melanoma cases from mucosal sites. ... As the gray phenotype, associated with progressive silvering of colored hair, has been linked to melanoma development in horses, we obtained a coat color phenotype for each case from clinical re…

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2019. Genetic and environmental risk factors for vitiligo and melanoma in Pura Raza Español horses. Equine Vet J — PubMed:PMID30624804 | DOI:10.1111/evj.13067 — OMIA Phene_Article / Article
  • 2022. DPF3, a putative candidate gene for melanoma etiopathogenesis in gray horses. J Equine Vet Sci — PubMed:PMID34801788 | DOI:10.1016/j.jevs.2021.103797 — OMIA Phene_Article / Article
  • 2023. Administration and detection of gene therapy in horses: A systematic review. Drug Test Anal — PubMed:PMID36269665 | DOI:10.1002/dta.3394 — OMIA Phene_Article / Article
  • 2013. Malignant melanoma in a grey horse: case presentation and review of equine melanoma treatment options. Ir Vet J — PubMed:PMID24196087 | DOI:10.1186/2046-0481-66-22 — OMIA Phene_Article / Article
  • 2023. Interventions for treatment of cutaneous melanoma in horses: a structured literature review. Vet Res Commun — PubMed:PMID36329228 | DOI:10.1007/s11259-022-10023-8 — OMIA Phene_Article / Article
  • 2013. Melanoma in horses: Current perspectives. Equine Veterinary Education — DOI:doi.org/10.1111/j.2042-3292.2011.00368.x — OMIA Phene_Article / Article
  • 2019. Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma. Nat Commun — PubMed:PMID30664638 | DOI:10.1038/s41467-018-08081-1 — OMIA Phene_Article / Article
  • 2024. White horses - non-coding sequences drive premature hair greying and predisposition to melanoma. Ups J Med Sci — PubMed:PMID38571883 | DOI:10.48101/ujms.v129.10626 — OMIA Phene_Article / Article
  • 2024. Predicted genetic burden and frequency of phenotype-associated variants in the horse. Sci Rep — PubMed:PMID38600096 | DOI:10.1038/s41598-024-57872-8 — OMIA Phene_Article / Article
  • 2024. Deregulation of metalloproteinase expression in gray horse melanoma ex vivo and in vitro. Cells — PubMed:PMID38891088 | DOI:10.3390/cells13110956 — OMIA Phene_Article / Article
  • 2024. An intronic copy number variation in Syntaxin 17 determines speed of greying and melanoma incidence in Grey horses. Nat Commun — PubMed:PMID39209879 | DOI:10.1038/s41467-024-51898-2 — OMIA Phene_Article / Article
  • 2024. Equine Melanoma Updates. Vet Clin North Am Equine Pract — PubMed:PMID39266414 | DOI:10.1016/j.cveq.2024.07.008 — OMIA Phene_Article / Article
  • (11 additional references in OMIA)

Sources

Horse (Equus caballus) — Melanoma, generic (hereditary; OMIA-verified species predisposition)
companion-species-healthPMID 30624804

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