Hamster — Hypertriglyceridemia (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Mesocricetus auratus / Phodopus spp. (hamster)Disorder: HypertriglyceridemiaSummary: Shen et al. (2024): Acute seizure models were established both in vivo and ex vivo using wild-type and Apolipoprotein C2 knockout ( Apoc2 −/− ) hamsters. ... Hypertriglyceridemic Apoc2 −/− hamsters exhibited reduced seizure frequency and decreased cortical neuron excitability." This study involves gene edited or genetically modified organisms (GMO).Defect: yes
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 398298976 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2020. ApoC2 deficiency elicits severe hypertriglyceridemia and spontaneous atherosclerosis: A rodent model rescued from neonatal death. Metabolism — PubMed:PMID32562799 | DOI:10.1016/j.metabol.2020.154296 — OMIA Phene_Article / Article
- 2024. Decreased neuronal excitability in hypertriglyceridemia hamsters with acute seizures. Front Neurol — PubMed:PMID39811454 | DOI:10.3389/fneur.2024.1500737 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:608083 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:207750 (type: None) — OMIA Group_OMIM (via OMIA_ID)