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Dog (Canis lupus familiaris) — Glioma, predisposition to (hereditary; OMIA-verified species predisposition)

companion_species_health_glioma_predisposition_to_dog

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--- license: permission_granted topic_id: companion_species_health_glioma_predisposition_to_dog category: companion-species-health title: "Dog (Canis lupus familiaris) — Glioma, predisposition to (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/dog_glioma_predisposition_to_3868.txt date_parsed: 2026-08-24 tokens_estimated: 161 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_glioma_predisposition_to_dog/01_companion_species_health_glioma_predisposition_to_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dog (Canis lupus familiaris) — Glioma, predisposition to (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA002012/9615/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Dog (Canis lupus familiaris) — Glioma, predisposition to (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Species: Dog (Canis lupus familiaris)
  • Disorder: Glioma, predisposition to
  • Summary: Truvé et al. (2016): "Gliomas are the most common form of malignant primary brain tumors in humans and second most common in dogs, occurring with similar frequencies in both species. Dogs are valuable spontaneous models of human complex diseases including cancers and may provide insight into disease susceptibility and oncogenesis. Several brachycephalic breeds such as Boxer, Bulldog and Boston Terrier have an elevated risk of developing glioma, but others, including Pug and Pekingese, are not at higher risk."

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIA molecular-genetics note: Truvé et al. (2016) "identified three candidate genes that were highly associated with glioma susceptibility: CAMKK2, P2RX7 and DENR. CAMKK2 showed reduced expression in both canine and human brain tumors, and a non-synonymous variant in P2RX7, previously demonstrated to have a 50% decrease in receptor function, was also associated with disease. Thus, one or more of these genes appear to affect gl…

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2006. Canine intracranial primary neoplasia: 173 cases (1986-2003). J Vet Intern Med — PubMed:PMID16734106 | DOI:10.1892/0891-6640(2006)20[669:cipnc]2.0.co;2 — OMIA Phene_Article / Article
  • 2016. Spontaneously arising canine glioma as a potential model for human glioma. J Comp Pathol — PubMed:PMID26804204 | DOI:10.1016/j.jcpa.2015.12.001 — OMIA Phene_Article / Article
  • 2010. Canine spontaneous glioma: a translational model system for convection-enhanced delivery. Neuro Oncol — PubMed:PMID20488958 | DOI:10.1093/neuonc/noq046 — OMIA Phene_Article / Article
  • 2010. IDH1 and IDH2 hotspot mutations are not found in canine glioma. Int J Cancer — PubMed:PMID19877121 | DOI:10.1002/ijc.25017 — OMIA Phene_Article / Article
  • 2000. Characterization of a canine glioma cell line as related to established experimental brain tumor models. J Neuropathol Exp Neurol — PubMed:PMID10901232 | DOI:10.1093/jnen/59.7.607 — OMIA Phene_Article / Article
  • 1995. What is your neurologic diagnosis? Cerebral glioma in a dog. J Am Vet Med Assoc — PubMed:PMID7744659 — OMIA Phene_Article / Article
  • 1988. Comparison of CT and MRI brain tumor imaging using a canine glioma model. Pediatr Neurol — PubMed:PMID3242530 | DOI:10.1016/0887-8994(88)90066-5 — OMIA Phene_Article / Article
  • 1987. Magnetic resonance brain tumor imaging in canine glioma. Neurology — PubMed:PMID3601090 | DOI:10.1212/wnl.37.7.1235 — OMIA Phene_Article / Article
  • 1974. Malignant glioma of the spinal cord in a dog. J Small Anim Pract — PubMed:PMID4449211 | DOI:10.1111/j.1748-5827.1974.tb05663.x — OMIA Phene_Article / Article
  • 1961. Glioma of the optic nerve of a dog. A case report. J Am Vet Med Assoc — PubMed:PMID13785456 — OMIA Phene_Article / Article
  • 2003. Glioblastoma multiforme: clinical findings, magnetic resonance imaging, and pathology in five dogs. Vet Pathol — PubMed:PMID14608019 | DOI:10.1354/vp.40-6-659 — OMIA Phene_Article / Article
  • 2013. Postmortem evaluation of 435 cases of intracranial neoplasia in dogs and relationship of neoplasm with breed, age, and body weight. J Vet Intern Med — PubMed:PMID23865437 | DOI:10.1111/jvim.12136 — OMIA Phene_Article / Article
  • (18 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:137800 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613028 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613029 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:607248 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613030 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613031 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613032 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613033 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:616568 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Sources

Dog (Canis lupus familiaris) — Glioma, predisposition to (hereditary; OMIA-verified species predisposition)
companion-species-healthPMID 16734106

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