--- license: permission_granted topic_id: companion_species_health_feline_alimentary_t_cell_lymphoma_epitheliotropic_intestinal_cat category: companion-species-health title: "Cat (Felis catus) — feline alimentary T cell lymphoma; epitheliotropic intestinal T-Cell lymphomas (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/cat_feline_alimentary_t_cell_lymphoma_epitheliotropic_intestinal_4916.txt date_parsed: 2026-08-24 tokens_estimated: 367 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_feline_alimentary_t_cell_lymphoma_epitheliotropic_intestinal_cat/01_companion_species_health_feline_alimentary_t_cell_lymphoma_epitheliotropic_intestinal_cat.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Cat (Felis catus) — feline alimentary T cell lymphoma; epitheliotropic intestinal T-Cell lymphomas (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA002526/9685/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Cat (Felis catus) — feline alimentary T cell lymphoma; epitheliotropic intestinal T-Cell lymphomas (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Cat (Felis catus)Disorder: feline alimentary T cell lymphoma; epitheliotropic intestinal T-Cell lymphomasSummary: Kieslinger et al. (2021): "Analysis of 42 samples of feline T cell alimentary lymphoma reveals broad activation of STAT3 and STAT5B. Screening for known activating mutations in STAT3 or STAT5B identifies the presence of the STAT5B^N642H [omia.variant:1425] driver mutation in feline enteropathy-associated T cell lymphoma in 7 out of 42 (16.67%) samples in total. Regarding lymphoma subtypes, the majority of mutations with 5 out of 17 (29.41%) cases were found in feline enteropathy-associated lymphoma type II (EATL II)." IT IS IMPORTANT TO NOTE THAT THIS IS UNDERSTOOD TO BE A SOMATIC MUTATION, WHICH MEANS THAT THE VARIANT IS NOT INHERITED AND WILL NOT BE PASSED ON TO OFFSPRING.Clin feat: A cat with EATL may present with a history of reduced or increased appetite, vomiting, lethargy, diarrhoea, constipation, and weight loss. Weight loss related to muscle wasting is the most common sign (Marsilio et al., 2023). The clinical findings in these cats may include abdominal pain or discomfort, muscle loss, diffusely thickened intestinal walls, enlarged mesenteric lymph nodes or masses within the abdomen. Clinical signs may be minimal or absent (Marsilio et al., 2023). IT thanks DVM student Lily Harford Sherringham, who provided the basis of this contribution in May 2023.
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 389721130 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2021. A recurrent STAT5B^N642H driver mutation in feline alimentary T cell lymphoma. Cancers (Basel) — PubMed:PMID34680385 | DOI:10.3390/cancers13205238 — OMIA Phene_Article / Article
- 2023. ACVIM consensus statement guidelines on diagnosing and distinguishing low-grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats. J Vet Intern Med — PubMed:PMID37130034 | DOI:10.1111/jvim.16690 — OMIA Phene_Article / Article
- 2012. Feline alimentary lymphoma: 1. Classification, risk factors, clinical signs and non-invasive diagnostics. J Feline Med Surg — PubMed:PMID22370860 | DOI:10.1177/1098612X12439265 — OMIA Phene_Article / Article
- 2022. Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas. Vet Sci — PubMed:PMID35448666 | DOI:10.3390/vetsci9040168 — OMIA Phene_Article / Article
- 2009. Low-grade alimentary lymphoma: clinicopathological findings and response to treatment in 17 cases. J Feline Med Surg — PubMed:PMID19576832 | DOI:10.1016/j.jfms.2009.05.021 — OMIA Phene_Article / Article
- 2021. Characterization of the intestinal mucosal proteome in cats with inflammatory bowel disease and alimentary small cell lymphoma. J Vet Intern Med — PubMed:PMID33471936 | DOI:10.1111/jvim.16003 — OMIA Phene_Article / Article
- 2012. Feline gastrointestinal lymphoma: mucosal architecture, immunophenotype, and molecular clonality. Vet Pathol — PubMed:PMID21505197 | DOI:10.1177/0300985811404712 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:604260 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:102578 (type: trait) — OMIA Group_OMIM (via OMIA_ID)