--- license: permission_granted topic_id: companion_species_health_exercise_induced_collapse_dog category: companion-species-health title: "Dog (Canis lupus familiaris) — Exercise-induced collapse (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/dog_exercise_induced_collapse_2885.txt date_parsed: 2026-08-24 tokens_estimated: 672 verification: method: substring_match claims: 9 passed: 9 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_exercise_induced_collapse_dog/01_companion_species_health_exercise_induced_collapse_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Dog (Canis lupus familiaris) — Exercise-induced collapse (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001466/9615/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Dog (Canis lupus familiaris) — Exercise-induced collapse (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Dog (Canis lupus familiaris)Disorder: Exercise-induced collapseMode of inheritance: Exercise-induced callapse in Labrador retrievers is a Mendelian trait. Norton et al. (2021) concluded that the disease in border collies (BCC) is a moderately- to highly-heritable complex polygenetic disease.Summary: Exercise-induced collapse (EIC) is an inherited neuromuscular disorder characterized by exercise intolerance in otherwise healthy young adult dogs. Clinical signs are precipitated by strenuous exercise. A causative mutation in dynamin 1 has been identified in retriever breeds listed below, but not yet in Border Collies. [Edited by Vicki N. Meyers-Wallen, VMD, PhD, Dipl. ACT in 2011; revised by FN 29 Oct 2020]Clin feat: Affected dogs have normal muscle mass, normal patellar reflexes before an episode of EIC, normal findings on muscle biopsy and are capable of moderate exertion without showing signs (Taylor et al., 2008, Patterson et al., 2008). Signs begin within 2 minutes after cessation of 5 to 15 minutes of strenuous exercise. Affected dogs develop a wobbly gait with hindlimb weakness and incoordination, wide based stance, and walking with crouched hind legs. Signs can progress to full body weakness, extensor rigidity, confusion, loss of consciousness, and rarely death. Episodes frequently last 5-10 minutes, often with complete recovery after 30 minutes. Loss of patellar reflexes persists after initial recovery.Pathology: Dynamin 1 is a type of GTPase that facilitates continuous neurotransmission across synapses. At the presynaptic terminal membrane, it assists in release of membrane vesicles containing neurotransmitter, which is needed for continuous synaptic communication (Patterson et al 2008). During high intensity exercise, DNM1 activity is inadequate to maintain synaptic transmission, which causes reversible loss of motor function (Patterson et al., 2008).Prevalence: In a population of 400 Labrador Retrievers from the Midwestern US, 37% were carriers and 3% were homozygous for the causative mutation. This suggests a high frequency of this mutation in Labrador Retrievers. Homozygous Labrador Retrievers have also been found in Europe, the Middle East, and Australia (Patterson et al., 2008).Control: It is recommended that working dogs or those showing signs be tested, as well as relatives of affected dogs. Breeding of homozygous dogs should be avoided. Breeding of carriers to noncarriers will avoid production of affected dogs. [updated 29 Oct 2020, with thanks to Frank Coopman]Gen test: A test is available to detect carriers and homozygotes (Patterson et al, 2008).
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 3487940 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: The causative mutation in Labrador retrievers, Chesapeake Bay retrievers and curly-coated retrievers is a G to T substitution in exon 6 that changes the amino acid codon from arginine to leucine (R256L) in a highly conserved region of DNM1 (Patterson et al., 2008).
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2008. A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Nat Genet — PubMed:PMID18806795 | DOI:10.1038/ng.224 — OMIA Phene_Article / Article
- 1999. Changes in rectal temperature and hematologic, biochemical, blood gas, and acid-base values in healthy Labrador Retrievers before and after strenuous exercise. Am J Vet Res — PubMed:PMID9918153 — OMIA Phene_Article / Article
- 2011. Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds. Vet J — PubMed:PMID21782486 | DOI:10.1016/j.tvjl.2011.06.022 — OMIA Phene_Article / Article
- 2009. Evaluations of labrador retrievers with exercise-induced collapse, including response to a standardized strenuous exercise protocol. J Am Anim Hosp Assoc — PubMed:PMID19122058 — OMIA Phene_Article / Article
- 2008. Exercise-induced collapse of Labrador retrievers: survey results and preliminary investigation of heritability. J Am Anim Hosp Assoc — PubMed:PMID18981194 — OMIA Phene_Article / Article
- 2012. Genotyping of exercise-induced collapse in Labrador retrievers using an allele-specific PCR. Vet J — PubMed:PMID22104507 | DOI:10.1016/j.tvjl.2011.10.018 — OMIA Phene_Article / Article
- 2011. [Frequency of gene defects in selected European retriever populations]. Schweiz Arch Tierheilkd — PubMed:PMID21866517 | DOI:10.1024/0036-7281/a000236 — OMIA Phene_Article / Article
- 2013. Suspected exercise-induced seizures in a young dog. J Small Anim Pract — PubMed:PMID23387942 | DOI:10.1111/jsap.12028 — OMIA Phene_Article / Article
- 2013. Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers. J Am Vet Med Assoc — PubMed:PMID23445289 | DOI:10.2460/javma.242.6.786 — OMIA Phene_Article / Article
- 2013. The prevalence of nine genetic disorders in a dog population from Belgium, the Netherlands and Germany. PLoS One — PubMed:PMID24069350 | DOI:10.1371/journal.pone.0074811 — OMIA Phene_Article / Article
- 2016. Evaluation of Dogs with Border Collie Collapse, Including Response to Two Standardized Strenuous Exercise Protocols. J Am Anim Hosp Assoc — PubMed:PMID27487345 | DOI:10.5326/JAAHA-MS-6361 — OMIA Phene_Article / Article
- 2016. Border Collie Collapse: Owner Survey Results and Veterinary Description of Videotaped Episodes. J Am Anim Hosp Assoc — PubMed:PMID27685362 | DOI:10.5326/JAAHA-MS-6436 — OMIA Phene_Article / Article
- (4 additional references in OMIA)
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:602377 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:616346 (type: trait) — OMIA Group_OMIM (via OMIA_ID)