--- license: permission_granted topic_id: companion_species_health_difference_of_sexual_development_dmrt1_related_rabbit category: companion-species-health title: "Rabbit (Oryctolagus cuniculus) — Difference of sexual development, DMRT1-related (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/rabbit_difference_of_sexual_development_dmrt1_related_5682.txt date_parsed: 2026-08-24 tokens_estimated: 174 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_difference_of_sexual_development_dmrt1_related_rabbit/01_companion_species_health_difference_of_sexual_development_dmrt1_related_rabbit.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Rabbit (Oryctolagus cuniculus) — Difference of sexual development, DMRT1-related (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001709/9986/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Rabbit (Oryctolagus cuniculus) — Difference of sexual development, DMRT1-related (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Rabbit (Oryctolagus cuniculus)Disorder: Difference of sexual development, DMRT1-relatedSummary: Dujardin et al. (2023) "abolished DMRT1 expression by CRISPR/Cas9 in ... the rabbit. First, we observed that gonads from XY DMRT1−/− rabbit fetuses differentiated like ovaries, highlighting that DMRT1 is involved in testis determination. ... Second, we highlighted another function of DMRT1 in the germline since XX and XY DMRT1−/− ovaries did not undergo meiosis and folliculogenesis. XX DMRT1−/− adult females were sterile, showing that DMRT1 is also crucial for female fertility." This study involves genetically modified organisms (GMO).
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 389106167 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2023. DMRT1 is a testis-determining gene in rabbits and is also essential for female fertility. Elife — PubMed:PMID37847154 | DOI:10.7554/eLife.89284 — OMIA Phene_Article / Article
- 2024. [Dmrt1 is a major gene for testicular determination and for male and female fertility in rabbits]. Med Sci (Paris) — PubMed:PMID38520096 | DOI:10.1051/medsci/2024004 — OMIA Phene_Article / Article
- 2025. DMRT1 haploinsufficiency leads to secondary infertility in XY male rabbits. Biol Reprod — PubMed:PMID40169148 | DOI:10.1093/biolre/ioaf064 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:602424 (type: gene) — OMIA Group_OMIM (via OMIA_ID)