Rabbit (Oryctolagus cuniculus) — Diabetes mellitus (hereditary; OMIA-verified species predisposition)

--- license: permission_granted topic_id: companion_species_health_diabetes_mellitus_rabbit category: companion-species-health title: "Rabbit (Oryctolagus cuniculus) — Diabetes mellitus (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/rabbit_diabetes_mellitus_2526.txt date_parsed: 2026-08-24 tokens_estimated: 123 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_diabetes_mellitus_rabbit/01_companion_species_health_diabetes_mellitus_rabbit.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Rabbit (Oryctolagus cuniculus) — Diabetes mellitus (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA000279/9986/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---

Rabbit (Oryctolagus cuniculus) — Diabetes mellitus (hereditary; OMIA-verified species predisposition)

Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Species: Rabbit (Oryctolagus cuniculus)
• Disorder: Diabetes mellitus
• Summary: Song et al. (2019) developed a "rabbit with a non-frameshift mutation of GCK gene (GCK-NFS) by cytoplasm microinjection of Cas9 mRNA and gRNA. These GCK-NFS rabbits showed typical features of MODY-2 including hyperglycemia and glucose intolerance with similar survival rate and weight compared to wild-type (WT) rabbits." This is a genetically-modified organism (GMO).

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: Entrez Gene ID 389108310 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 1998. Diabetes mellitus in rabbits, guinea pigs and chinchillas [German]. Kleintierpraxis — OMIA Phene_Article / Article
• 2019. Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2. Cell Mol Life Sci — PubMed:PMID31720743 | DOI:10.1007/s00018-019-03354-4 — OMIA Phene_Article / Article
• 2023. Contribution of animal models to diabetes research: Its history, significance, and translation to humans. J Diabetes Investig — PubMed:PMID37401013 | DOI:10.1111/jdi.14034 — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:125850 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:125851 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:125852 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:125853 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:176730 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:222100 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:222300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:520000 (type: trait) — OMIA Group_OMIM (via OMIA_ID)