--- license: permission_granted topic_id: companion_species_health_deficient_acetaminophen_glucuronidation_cat category: companion-species-health title: "Cat (Felis catus) — Deficient acetaminophen glucuronidation (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/cat_deficient_acetaminophen_glucuronidation_3112.txt date_parsed: 2026-08-24 tokens_estimated: 80 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_deficient_acetaminophen_glucuronidation_cat/01_companion_species_health_deficient_acetaminophen_glucuronidation_cat.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Cat (Felis catus) — Deficient acetaminophen glucuronidation (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001586/9685/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Cat (Felis catus) — Deficient acetaminophen glucuronidation (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Cat (Felis catus)Disorder: Deficient acetaminophen glucuronidationGen test: Since all cats lack this gene, there is no need for any genetic testing
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 83148755 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: By cloning and sequencing a very likely candidate gene (based on the observation that "The domestic cat has a significantly lower capacity to glucuronidate planar phenolic xenobiotics compared with most other mammalian species"), Court and Greenblatt (2000) showed that all cats are homozygous for a mutated form of the UGT1A6 gene that encodes UDP-glucuronosyltransferase 1A6, and hence completely l…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2011. Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory. PLoS One — PubMed:PMID21464924 | DOI:10.1371/journal.pone.0018046 — OMIA Phene_Article / Article
- 2000. Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms. Pharmacogenetics — PubMed:PMID10862526 — OMIA Phene_Article / Article
- 1958. Do cats form glucuronides?. Biochemical journal — OMIA Phene_Article / Article
- 1972. The fate of (14C)phenol in various species. Xenobiotica — PubMed:PMID4211177 — OMIA Phene_Article / Article
- 1997. Molecular basis for deficient acetaminophen glucuronidation in cats. An interspecies comparison of enzyme kinetics in liver microsomes. Biochem Pharmacol — PubMed:PMID9174118 — OMIA Phene_Article / Article
- 1972. Species differences in biotransformation and excretion of salicylate. Am J Vet Res — PubMed:PMID5022404 — OMIA Phene_Article / Article
- 1984. The toxicity and biotransformation of single doses of acetaminophen in dogs and cats. Toxicol Appl Pharmacol — PubMed:PMID6729821 — OMIA Phene_Article / Article
- 1997. Biochemical basis for deficient paracetamol glucuronidation in cats: an interspecies comparison of enzyme constraint in liver microsomes. J Pharm Pharmacol — PubMed:PMID9232546 — OMIA Phene_Article / Article
- 2014. Comparing the glucuronidation capacity of the feline liver with substrate-specific glucuronidation in dogs. J Vet Pharmacol Ther — PubMed:PMID23888985 | DOI:10.1111/jvp.12067 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:606431 (type: gene) — OMIA Group_OMIM (via OMIA_ID)