--- license: permission_granted topic_id: companion_species_health_cystic_fibrosis_rabbit category: companion-species-health title: "Rabbit (Oryctolagus cuniculus) — Cystic fibrosis (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/rabbit_cystic_fibrosis_5849.txt date_parsed: 2026-08-24 tokens_estimated: 80 verification: method: substring_match claims: 3 passed: 3 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_cystic_fibrosis_rabbit/01_companion_species_health_cystic_fibrosis_rabbit.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Rabbit (Oryctolagus cuniculus) — Cystic fibrosis (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001794/9986/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Rabbit (Oryctolagus cuniculus) — Cystic fibrosis (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Rabbit (Oryctolagus cuniculus)Disorder: Cystic fibrosisSummary: Yang et al. (2020) "report the production of CFTR-ΔF508 rabbits by CRISPR/Cas9-mediated gene editing." This study involves genetically modified organisms (GMO).
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 398298869 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2024. Sotagliflozin attenuates liver associated disorders in cystic fibrosis rabbits. JCI Insight — PubMed:PMID38358827 | DOI:10.1172/jci.insight.165826 — OMIA Phene_Article / Article
- 2021. Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene. JCI Insight — PubMed:PMID33232302 | DOI:10.1172/jci.insight.139813 — OMIA Phene_Article / Article
- 2020. Production of CFTR-ΔF508 rabbits. Front Genet — PubMed:PMID33552140 | DOI:10.3389/fgene.2020.627666 — OMIA Phene_Article / Article
- 2023. Cystic fibrosis rabbits develop spontaneous hepatobiliary lesions and CF-associated liver disease (CFLD)-like phenotypes. PNAS Nexus — PubMed:PMID36712930 | DOI:10.1093/pnasnexus/pgac306 — OMIA Phene_Article / Article
- 2021. Intestinal dysbiosis in young cystic fibrosis rabbits. J Pers Med — PubMed:PMID33669429 | DOI:10.3390/jpm11020132 — OMIA Phene_Article / Article
- 2024. Endocrine pathology in young rabbits with cystic fibrosis. eGastroenterology — PubMed:PMID39605883 | DOI:10.1136/egastro-2024-100102 — OMIA Phene_Article / Article
- 2026. Male reproductive phenotype in cystic fibrosis: comparison of existing animal models. Lab Anim (NY) — PubMed:PMID42380629 | DOI:10.1038/s41684-026-01763-0 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:219700 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:602421 (type: gene) — OMIA Group_OMIM (via OMIA_ID)