--- license: permission_granted topic_id: companion_species_health_c3_deficiency_rabbit category: companion-species-health title: "Rabbit (Oryctolagus cuniculus) — C3 deficiency (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/rabbit_c3_deficiency_29.txt date_parsed: 2026-08-24 tokens_estimated: 210 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_c3_deficiency_rabbit/01_companion_species_health_c3_deficiency_rabbit.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Rabbit (Oryctolagus cuniculus) — C3 deficiency (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA000155/9986/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Rabbit (Oryctolagus cuniculus) — C3 deficiency (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Rabbit (Oryctolagus cuniculus)Disorder: C3 deficiencySummary: C3 deficiency was discovered in a line of rabbits undergoing selection for high and low total complement haemolytic activity (Komatsu, 1985). Preliminary molecular studies by Komatsu (1992) showed that the mutant allele produces only very low levels of C3 mRNA, suggesting a mutation in a control region of the gene. Sequencing is now underway to determine the exact molecular defect.Clin feat: 10% of normal C3 serum levels; low survival rate; reduced serum bactericidal activity; suppressed delayed-type hypersensitivityGen test: Using a 1.6 kb fragment of rabbit C2 cDNA as a probe in Southern analysis, the three genotypes at this locus can be detected with either BglII, StuI, or SacI (Komatsu, 1992).
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIA entry symbol: C3D (no structured Phene_Gene link)
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1988. Hereditary C3 hypocomplementemia in the rabbit. Immunology — PubMed:PMID3410489 — OMIA Phene_Article / Article
- 1992. Molecular Biology for Genetic Deficiencies of Complement Components in Rabbits - C8alpha-gamma Deficiency and C3- Hypocomplementemia. JARQ - Japan Agricultural Research Quarterly — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:613779 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:120700 (type: gene) — OMIA Group_OMIM (via OMIA_ID)