--- license: permission_granted topic_id: companion_species_health_burmese_hypokalaemic_periodic_polymyopathy_bhp_cat category: companion-species-health title: "Cat (Felis catus) — Burmese hypokalaemic periodic polymyopathy (BHP) (hereditary; OMIA-verified species predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-24 from local OMIA database dump." source_file: pdf-raw/species-health/cat_burmese_hypokalaemic_periodic_polymyopathy_bhp_3431.txt date_parsed: 2026-08-24 tokens_estimated: 229 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-24 recovered: false path: companion-species-health/companion_species_health_burmese_hypokalaemic_periodic_polymyopathy_bhp_cat/01_companion_species_health_burmese_hypokalaemic_periodic_polymyopathy_bhp_cat.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Cat (Felis catus) — Burmese hypokalaemic periodic polymyopathy (BHP) (hereditary; OMIA-verified species predisposition)" url: "https://omia.org/OMIA001759/9685/" retrieved: "2026-08-24" ref: "OMIA species-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (species-specific disorder entries)" needs_review: false
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."---
Cat (Felis catus) — Burmese hypokalaemic periodic polymyopathy (BHP) (hereditary; OMIA-verified species predisposition)
Source: first-hand OMIA (University of Sydney) species-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Species: Cat (Felis catus)Disorder: Burmese hypokalaemic periodic polymyopathy (BHP)Mode of inheritance: Mason (1988; Journal of the American Animal Hospital Association 24:147-151) provided evidence of autosomal recessive inheritance in Burmese cats.Clin feat: "Classically, signs of BHP are episodic but in some cats, the weakness is incessant. During an episode, muscle pain (myalgia) from palpation can be a prominent sign. Cats can present with severe generalized muscle weakness, although more commonly weakness of the cervical muscles as evidenced by ventroflexion of the head and neck, head bobbing and dorsal protrusion of the scapulae . . . . The gait becomes short and maximal recruitment of motor units gives rise to muscle tremor. Cats with more generalized weakness have a crouching gait, especially evident in the hind limbs." (Gandolfi et al., 2012)
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 389728003 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Sequencing of the only two candidate genes in the region of chromosome FCA E1 to which the disorder had been mapped (see Mapping section above) revealed a causative mutation in the WNK4 gene (omia.variant:312) as "(c.2899C.T) [which] causes a premature stop codon (CAG.TAG)" (Gandolfi et al., 2012). This mutation leads "to a truncated protein that lacks the C-terminal coiled-coil domain and the hig…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1998. Periodic muscle weakness and cervical ventroflexion caused by hypokalemia in a Burmese cat [Dutch]. Tijdschr Diergeneeskd — PubMed:PMID9700861 — OMIA Phene_Article / Article
- 1986. Periodic muscle weakness in Burmese kittens. Vet Rec — PubMed:PMID3727333 | DOI:10.1136/vr.118.22.619 — OMIA Phene_Article / Article
- 1989. Hypokalemia in cats: 186 cases (1984-1987). J Am Vet Med Assoc — PubMed:PMID2753783 — OMIA Phene_Article / Article
- 1990. Hypokalemia in the cat. Cornell Vet — PubMed:PMID2403422 — OMIA Phene_Article / Article
- 2010. Severe life-threatening hypokalemia in a cat with suspected distal renal tubular acidosis. J Vet Emerg Crit Care (San Antonio) — PubMed:PMID20487254 | DOI:10.1111/j.1476-4431.2009.00490.x — OMIA Phene_Article / Article
- 1988. Hypokalaemic myopathy in Burmese kittens. N Z Vet J — PubMed:PMID16031474 | DOI:10.1080/00480169.1988.35514 — OMIA Phene_Article / Article
- 1988. Hereditary potassium depletion in Burmese cats. Journal of the American Animal Hospital Association — OMIA Phene_Article / Article
- 1984. Feline polymyopathy. Proceedings of the 2nd Annual Forum of the American College of Veterinary Internal Medicine — OMIA Phene_Article / Article
- 1987. Potassium depletion in cats: hypokalemic polymyopathy. J Am Vet Med Assoc — PubMed:PMID3693009 — OMIA Phene_Article / Article
- 1989. Sporadic feline hypokalaemic polymyopathy. Vet Rec — PubMed:PMID2781689 | DOI:10.1136/vr.125.1.17 — OMIA Phene_Article / Article
- 2001. Periodic hypokalemic polymyopathy in the Burmese cat. Kleintierpraxis — OMIA Phene_Article / Article
- 2012. First WNK4-hypokalemia animal model identified by genome-wide association in Burmese cats. PLoS One — PubMed:PMID23285264 | DOI:10.1371/journal.pone.0053173 — OMIA Phene_Article / Article
- (10 additional references in OMIA)
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:601844 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:614491 (type: trait) — OMIA Group_OMIM (via OMIA_ID)