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Thai Ridgeback — ridge; hair ridge; dermoid cyst (hereditary; OMIA-verified breed predisposition)

companion_breed_health_thai_ridgeback_ridge_hair_ridge_dermoid_cyst_dog

companion-breed-health en

--- license: permission_granted topic_id: companion_breed_health_thai_ridgeback_ridge_hair_ridge_dermoid_cyst_dog category: companion-breed-health title: "Thai Ridgeback — ridge; hair ridge; dermoid cyst (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/thai_ridgeback_ridge_hair_ridge_dermoid_cyst_515.txt date_parsed: 2026-08-02 tokens_estimated: 389 verification: method: substring_match claims: 6 passed: 6 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_thai_ridgeback_ridge_hair_ridge_dermoid_cyst_dog/01_companion_breed_health_thai_ridgeback_ridge_hair_ridge_dermoid_cyst_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Thai Ridgeback — ridge; hair ridge; dermoid cyst (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000272/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Thai Ridgeback — ridge; hair ridge; dermoid cyst (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: Thai Ridgeback (Dog)
  • Disorder: ridge; hair ridge; dermoid cyst
  • Mode of inheritance: [T]he ridge trait [in Rhodesian Ridgeback dogs] is inherited in a dominant fashion; thus a single copy of this duplication results in appearance of a ridge, and dogs with two copies of the duplication are indistinguishable from dogs with one copy (Waldo and Diaz, 2015) Homozygotes for the Ridge allele are more likely to also have a dermoid sinus (Salmon Hillbertz et al., 2007). Inheritance of dermoid sinuses in other breeds is less well documented.
  • Summary: Dermoid sinuses and cysts have been described in dogs from several breeds. Hillbertz and Andersson (2006) reported that in the Rhodesian ridgeback population, dogs with the autosomal dominant ridge are predisposed to dermoid sinuses. Salmon Hillbertz et al. (2007) identified the causative mutation for the autosomal dominant dorsal hair ridge in Rhodesian and Thai Ridgeback dogs and proposed that the mutation predisposes to dermoid sinus with low penetrance in duplication heterozygotes and with high penetrance in homozygotes.
  • Defect: yes
  • Gen test: Waldo and Diaz (2015) reported a useful diagnostic test for the duplication causing the ridge allele detailed above. While homozygotes and heterozygotes for the duplication (Ridge allele) have identical ridge appearance (characteristic of ridged breeds), homozygotes for the Ridge allele are more likely to also have a dermoid sinus (Salmon Hillbertz et al., 2007).

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • Gene: Entrez Gene ID 3482387 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
  • Gene: Entrez Gene ID 23858819 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
  • Gene: Entrez Gene ID 388306198 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
  • Gene: Entrez Gene ID 388306207 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
  • OMIA molecular-genetics note: The 750kb candidate region on CFA18 identified by Karlsson et al. (2007) (see Mapping section) contains five genes, three of which are fibroblast growth factor (FGF) genes that in chickens have an integral role in embryonic development. In an accompanying paper in the same issue of Nature Genetics, Salmon Hillbertz et al. (2007) reported that the hair-ridge phenotype (which predisposes to dermoid …

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1966. Dermoid sinus in the Rhodesian Ridgeback. Journal of Small Animal Practice — PubMed:PMID5951011 | DOI:10.1111/j.1748-5827.1966.tb04388.x — OMIA Phene_Article / Article
  • 1957. Mid dorsal dermoid sinuses in Rhodesian Ridgeback dogs - a case report. Journal of the American Veterinary Medical Association — OMIA Phene_Article / Article
  • 1993. Dermoid Sinus in a Rhodesian Ridgeback. Journal of Small Animal Practice — OMIA Phene_Article / Article
  • 1995. Dermoid sinus and spinal malformations in a Yorkshire terrier: Diagnosis and follow-up. Journal of Small Animal Practice — PubMed:PMID7603060 — OMIA Phene_Article / Article
  • 1998. Atypical dermoid sinus in a chow chow dog. Journal of the South African Veterinary Medical Association — OMIA Phene_Article / Article
  • 1999. A dermoid sinus in a Siberian Husky. Veterinary Dermatology — OMIA Phene_Article / Article
  • 2000. True dermoid cyst in a Rhodesian ridgeback. Journal of Small Animal Practice — PubMed:PMID11002937 — OMIA Phene_Article / Article
  • 2007. Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Nat Genet — PubMed:PMID17906623 | DOI:10.1038/ng.2007.4 — OMIA Phene_Article / Article
  • 2007. Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet — PubMed:PMID17906626 | DOI:10.1038/ng.2007.10 — OMIA Phene_Article / Article
  • 2009. Genome-wide association analysis in domestic animals: a powerful approach for genetic dissection of trait loci. Genetica — PubMed:PMID18704695 | DOI:10.1007/s10709-008-9312-4 — OMIA Phene_Article / Article
  • 2008. Magnetic resonance imaging in the diagnosis of type 1 dermoid sinus in two Rhodesian Ridgeback dogs. J Small Anim Pract — PubMed:PMID10713979 | DOI:10.1111/j.1748-5827.2000.tb03132.x — OMIA Phene_Article / Article
  • 2006. Autosomal dominant mutation causing the dorsal ridge predisposes for dermoid sinus in Rhodesian ridgeback dogs. J Small Anim Pract — PubMed:PMID16573760 | DOI:10.1111/j.1748-5827.2006.00016.x — OMIA Phene_Article / Article
  • (15 additional references in OMIA)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Sources

Thai Ridgeback — ridge; hair ridge; dermoid cyst (hereditary; OMIA-verified breed predisposition)
companion-breed-healthPMID 5951011

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