--- license: permission_granted topic_id: companion_breed_health_siberian_husky_omia2115_dog category: companion-breed-health title: "Siberian Husky — Goniodysgenesis (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/siberian_husky_omia2115_2115.txt date_parsed: 2026-08-02 tokens_estimated: 136 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_siberian_husky_omia2115_dog/01_companion_breed_health_siberian_husky_omia2115_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Siberian Husky — Goniodysgenesis (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001223/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Siberian Husky — Goniodysgenesis (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Siberian Husky (Dog)Disorder:Mode of inheritance: Autosomal recessiveSummary: Genetics Committee of the American College of Veterinary Opthalmologists (2021): congenital anomaly characterized by the persistence of a variably fenestrated sheet of uveal tissue spanning the iridocorneal angle, extending from the iris base to the peripheral cornea. Diagnosis is by gonioscopy, which is not part of a routine eye certification examination.Defect: yes
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 388249798 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Pugh et al. (2019) reported that analysis of "Whole genome sequences [in the candidate region] of three dogs with glaucoma, three severely affected by goniodysgenesis and three unaffected dogs identified a missense variant [c.590G>A] in the olfactomedin like 3 (OLFML3) gene in all six affected animals."
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1996. Mesodermal goniodysplasia in the Siberian Husky [German]. Kleintierpraxis — OMIA Phene_Article / Article
- 1996. Goniodysgenesis in the bouvier des flandres dog [German]. Schweizer Archiv fur Tierheilkunde — PubMed:PMID8765546 — OMIA Phene_Article / Article
- 1998. Pectinate ligament dysplasia and glaucoma in Flat Coated Retrievers. II. Assessment of prevalence and heritability. Vet Ophthalmol — PubMed:PMID11397216 | DOI:10.1046/j.1463-5224.1998.00020.x — OMIA Phene_Article / Article
- 2015. Progression of pectinate ligament dysplasia over time in two populations of Flat-Coated Retrievers. Vet Ophthalmol — PubMed:PMID24025050 | DOI:10.1111/vop.12098 — OMIA Phene_Article / Article
- 2016. Prevalence of pectinate ligament dysplasia and associations with age, sex and intraocular pressure in the Basset hound, Flatcoated retriever and Dandie Dinmont terrier. Canine Genet Epidemiol — PubMed:PMID26973793 | DOI:10.1186/s40575-016-0033-1 — OMIA Phene_Article / Article
- 2019. Arginine to glutamine variant in olfactomedin like 3 (OLFML3) is a candidate for severe goniodysgenesis and glaucoma in the Border Collie dog breed. G3 (Bethesda) — PubMed:PMID30696701 | DOI:10.1534/g3.118.200944 — OMIA Phene_Article / Article
- 2016. Survey of the incidence of pectinate ligament dysplasia and glaucoma in the UK Leonberger population. Vet Ophthalmol — PubMed:PMID26359130 | DOI:10.1111/vop.12311 — OMIA Phene_Article / Article
- 2017. Pectinate ligament dysplasia in the Border Collie, Hungarian Vizsla and Golden Retriever. Vet Rec — PubMed:PMID27999154 | DOI:10.1136/vr.104121 — OMIA Phene_Article / Article
- 1991. Correlation of morphologic features of the iridocorneal angle to intraocular pressure in Samoyeds. Am J Vet Res — PubMed:PMID1785731 — OMIA Phene_Article / Article
- 2019. A variant in OLFML3 is associated with pectinate ligament abnormality and primary closed-angle glaucoma in Border Collies from the United Kingdom. Vet Ophthalmol — PubMed:PMID31141290 | DOI:10.1111/vop.12680 — OMIA Phene_Article / Article
- 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:137600 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:137750 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:138770 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."