--- license: permission_granted topic_id: companion_breed_health_new_zealand_heading_dog_omia3896_dog category: companion-breed-health title: "New Zealand Heading Dog — Lundehund syndrome (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/new_zealand_heading_dog_omia3896_3896.txt date_parsed: 2026-08-02 tokens_estimated: 165 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_new_zealand_heading_dog_omia3896_dog/01_companion_breed_health_new_zealand_heading_dog_omia3896_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "New Zealand Heading Dog — Lundehund syndrome (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA002031/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
New Zealand Heading Dog — Lundehund syndrome (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: New Zealand Heading Dog (Dog)Disorder:Mode of inheritance: Autosomal recessiveClin feat: Metzger et al. (2016): the Lundehund harbors a breed disposition for a syndrome comprising particular features of protein-losing enteropathy (PLE), intestinal lymphangiectasia, gastrointestinal disturbance, inflammatory bowel disease and malabsorption designated as Lundehund syndrome (LS) . . . . Clinical signs are diarrhea, vomiting, weight loss, edema and apathy often accompanied with decreased concentrations of albumin and globulin in blood profileDefect: yes
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: LEPREL1 (Entrez Gene ID 388246610) — OMIA Phene_Gene / GeneSynonym
- OMIA molecular-genetics note: Metzger et al. (2016): "Filtering analysis for variants with predicted high or moderate effects revealed a missense mutation in LEPREL1 [also known as P3H2] 1.2 Mb proximal to the region of the genome-wide association, which was shown to be significantly associated with LS."
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1977. Protein losing enteropathy in the Lundehund. J Small Anim Pract — PubMed:PMID853728 | DOI:10.1111/j.1748-5827.1977.tb05819.x — OMIA Phene_Article / Article
- 2016. Variant detection and runs of homozygosity in next generation sequencing data elucidate the genetic background of Lundehund syndrome. BMC Genomics — PubMed:PMID27485430 | DOI:10.1186/s12864-016-2844-6 — OMIA Phene_Article / Article
- 1994. Gastropathies in the Lundehund. I. Gastritis and gastric neoplasia associated with intestinal lymphangiectasia. APMIS — PubMed:PMID7946268 — OMIA Phene_Article / Article
- 2015. Effective population size, extended linkage disequilibrium and signatures of selection in the rare dog breed lundehund. PLoS One — PubMed:PMID25860808 | DOI:10.1371/journal.pone.0122680 — OMIA Phene_Article / Article
- 2023. Gut microbiome dysbiosis is associated with host genetics in the Norwegian Lundehund. Front Microbiol — PubMed:PMID37405168 | DOI:10.3389/fmicb.2023.1209158 — OMIA Phene_Article / Article
- 2023. Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture. Genome Biol — PubMed:PMID37582787 | DOI:10.1186/s13059-023-03023-7 — OMIA Phene_Article / Article
- 2025. Survey of functional Mendelian variants in New Zealand Huntaway and Heading dog breeds. Anim Genet — PubMed:PMID40965331 | DOI:10.1111/age.70042 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:610341 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."