--- license: permission_granted topic_id: companion_breed_health_mixed_breed_omia6871_dog category: companion-breed-health title: "Mixed Breed — Phloiokeratosis, SUV39H1-related (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/mixed_breed_omia6871_6871.txt date_parsed: 2026-08-02 tokens_estimated: 163 verification: method: substring_match claims: 6 passed: 6 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_mixed_breed_omia6871_dog/01_companion_breed_health_mixed_breed_omia6871_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Mixed Breed — Phloiokeratosis, SUV39H1-related (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA003060/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Mixed Breed — Phloiokeratosis, SUV39H1-related (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Mixed Breed (Dog)Disorder:Mode of inheritance: X-linked incomplete dominantClin feat: Kiener et al. (2026): Affected dogs presented with multifocal hyperkeratotic skin lesions. The lesions in male dogs were arranged in a bilaterally symmetrical distribution, whereas in several female cases, lesions followed Blaschko lines and were not symmetric. ... nbsp;The appearance of the lesions was reminiscent of tree bark.Defect: yesPathology: Kiener et al. (2026) describe histological changes as severe mostly compact epidermal and infundibular hyperkeratosis.
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 398299109 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Kiener et al. (2026) conducted whole genome sequencing of six affected dogs from four different families including parents of two affected animals: "Whole genome sequencing revealed four independent variants in the SUV39H1 gene [omia.variant:1904-1907] encoding an H3K9 methyltransferase, which is involved in epigenetic silencing of chromatin."
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2026. Phloiokeratosis is a new ichthyosiform hyperkeratotic cornification disorder in dogs with SUV39H1 variants. Sci Rep — PubMed:PMID42350566 | DOI:10.1038/s41598-026-59288-y — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:300254 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."