--- license: permission_granted topic_id: companion_breed_health_lagotto_romagnolo_omia3009_dog category: companion-breed-health title: "Lagotto Romagnolo — Curly coat (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/lagotto_romagnolo_omia3009_3009.txt date_parsed: 2026-08-02 tokens_estimated: 195 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_lagotto_romagnolo_omia3009_dog/01_companion_breed_health_lagotto_romagnolo_omia3009_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Lagotto Romagnolo — Curly coat (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000245/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Lagotto Romagnolo — Curly coat (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Lagotto Romagnolo (Dog)Disorder:Mode of inheritance: AutosomalDefect: noPrevalence: Bauer et al. (2019) found that the [c.1266_1273delinsACA] variant was fixed in a cohort of 125 Curly Coated Retrievers and segregating in five of 14 additionally tested breeds with a curly or wavy coat. Salmela et al. (2019): The [c.1266_1273delinsACA] variant was also found at lower frequencies in five other breeds, including Lagotto Romagnolo, Bichon Frise, Spanish Water Dog, Chesapeake Bay Retriever and Irish Terrier. These authors also reported that One curly-coated Lagotto carried neither of the two KRT71 variants, indicating that not all the likely causal variants have yet been discovered.
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 23860798 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Fine-mapping and subsequent sequencing within the candidate region on CFA27 (see Mapping section) enabled Cadieu et al. (2009) to identify the causal mutation as a missense SNP (Arg151Trp) in the KRT71 gene. In adjacent papers published online just three days apart, Bauer et al. (2019) and Salmela et al. (2019) independently reported a second likely causal variant (c.1266_1273delinsACA) in Curly C…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2009. Coat variation in the domestic dog is governed by variants in three genes. Science — PubMed:PMID19713490 | DOI:10.1126/science.1177808 — OMIA Phene_Article / Article
- 2012. Keratin 71 mutations: from water dogs to woolly hair. J Invest Dermatol — PubMed:PMID22971920 | DOI:10.1038/jid.2012.291 — OMIA Phene_Article / Article
- 2017. The bald and the beautiful: hairlessness in domestic dog breeds. Philos Trans R Soc Lond B Biol Sci — PubMed:PMID27994129 | DOI:10.1098/rstb.2015.0488 — OMIA Phene_Article / Article
- 2019. A second KRT71 allele in curly coated dogs. Anim Genet — PubMed:PMID30444027 | DOI:10.1111/age.12743 — OMIA Phene_Article / Article
- 2019. A novel KRT71 variant in curly-coated dogs. Anim Genet — PubMed:PMID30456859 | DOI:10.1111/age.12746 — OMIA Phene_Article / Article
- 2019. True Colors: Commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential. PLoS One — PubMed:PMID31658272 | DOI:10.1371/journal.pone.0223995 — OMIA Phene_Article / Article
- 2021. Corrigendum: A second KRT71 allele in curly coated dogs. Anim Genet — PubMed:PMID34196995 | DOI:10.1111/age.13098 — OMIA Phene_Article / Article
- 2023. Analysis of Doberman Pinscher and Toy Poodle samples with targeted next-generation sequencing. Gene — PubMed:PMID36427679 | DOI:10.1016/j.gene.2022.147069 — OMIA Phene_Article / Article
- 2023. Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture. Genome Biol — PubMed:PMID37582787 | DOI:10.1186/s13059-023-03023-7 — OMIA Phene_Article / Article
- 2025. Survey of functional Mendelian variants in New Zealand Huntaway and Heading dog breeds. Anim Genet — PubMed:PMID40965331 | DOI:10.1111/age.70042 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:608245 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."