--- license: permission_granted topic_id: companion_breed_health_kromfohrlander_hereditary_footpad_hyperkeratosis_dog category: companion-breed-health title: "Kromfohrlander — Hereditary Footpad Hyperkeratosis (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/kromfohrlander_hereditary_footpad_hyperkeratosis_2618.txt date_parsed: 2026-08-02 tokens_estimated: 202 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_kromfohrlander_hereditary_footpad_hyperkeratosis_dog/01_companion_breed_health_kromfohrlander_hereditary_footpad_hyperkeratosis_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Kromfohrlander — Hereditary Footpad Hyperkeratosis (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001327/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Kromfohrlander — Hereditary Footpad Hyperkeratosis (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Kromfohrlander (Dog)Disorder: Hereditary Footpad HyperkeratosisMode of inheritance: Autosomal recessiveClin feat: As summarised by Drögemüller et al. (2014): Hyperkeratosis of the foot pads is noticed by the owners of both breeds at 4–5 months of age and involves all footpads. With time horny protrusions appear on the rims of the footpads and the pad surface becomes hard and develops cracks . . . . Affected animals avoid walking on irregular surfaces and may go lame. The nails of affected dogs are very hard and seem to grow faster. We noticed a duller, less wiry, softer coat on an affected Kromfohrländer . . . . Similar clinical symptoms were noted on 5 HFH affected Irish Terriers.Defect: yes
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 389413015 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
- OMIA molecular-genetics note: Comparison of sequence in the positional candidate region, from whole-genome sequencing of an affected Kromfohrländer at 23.5x coverage, with relevant sequence from 46 non-affected dogs from other breeds identified the causal mutation as "a missense variant (c.155G>C) in the FAM83G gene encoding a protein with largely unknown function. It is predicted to change an evolutionary conserved arginin…
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 2000. Palmoplantar hyperkeratosis in Irish terriers: evidence of autosomal recessive inheritance. Journal of Small Animal Practice — PubMed:PMID10701186 — OMIA Phene_Article / Article
- 2003. Familial footpad hyperkeratosis and inheritance of keratin 2, keratin 9, and desmoglein 1 in two pedigrees of Irish Terriers. American Journal of Veterinary Research — PubMed:PMID12828257 — OMIA Phene_Article / Article
- 2014. A mutation in the FAM83G gene in dogs with hereditary footpad hyperkeratosis (HFH). PLoS Genet — PubMed:PMID24832243 | DOI:10.1371/journal.pgen.1004370 — OMIA Phene_Article / Article
- 2016. Whole-genome sequencing of a canine Family trio Reveals a FAM83G variant associated with hereditary footpad hyperkeratosis. G3 (Bethesda) — PubMed:PMID26747202 | DOI:10.1534/g3.115.025643 — OMIA Phene_Article / Article
- 2019. FAM83G/Fam83g genetic variants affect canine and murine hair formation. Exp Dermatol — PubMed:PMID29963719 | DOI:10.1111/exd.13729 — OMIA Phene_Article / Article
- 2021. Ichthyosis and hereditary cornification disorders in dogs. Vet Dermatol — PubMed:PMID34796560 | DOI:10.1111/vde.13033 — OMIA Phene_Article / Article
- 2022. Genetics of inherited skin disorders in dogs. Vet J — PubMed:PMID34861369 | DOI:10.1016/j.tvjl.2021.105782 — OMIA Phene_Article / Article
- 2023. Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture. Genome Biol — PubMed:PMID37582787 | DOI:10.1186/s13059-023-03023-7 — OMIA Phene_Article / Article
- 2021. Bedlington terriers diagnosed with familial footpad hyperkeratosis are carriers of an FAM83G mis-sense variant. In: 32nd European Veterinary Dermatology Congress (online) 16–16 September 2021 Abstracts. Veterinary Dermatology — DOI:10.1111/vde.13021 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:615886 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."