--- license: permission_granted topic_id: companion_breed_health_greyhound_omia4052_dog category: companion-breed-health title: "Greyhound — Polyneuropathy, NDRG1-related (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/greyhound_omia4052_4052.txt date_parsed: 2026-08-02 tokens_estimated: 662 verification: method: substring_match claims: 8 passed: 8 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_greyhound_omia4052_dog/01_companion_breed_health_greyhound_omia4052_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Greyhound — Polyneuropathy, NDRG1-related (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA002120/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false
Greyhound — Polyneuropathy, NDRG1-related (hereditary; OMIA-verified breed predisposition)
Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.
Claims
Breed: Greyhound (Dog)Disorder:Mode of inheritance: Autosomal recessiveSummary: The polyneuropathy of juvenile Greyhounds shows clinical similarities to the genetically heterogeneous Charcot-Marie-Tooth disease in humans.Clin feat: In Greyhounds, this polyneuropathy becomes evident in juvenile dogs between the ages of three and nine months (Drögemüller et al., 2010). Early clinical features include exercise intolerance (e.g. shaking and collapse after exercise), abnormal gait (e.g. bunny hopping and high stepping), while ataxia, dysphonia and severe muscle atrophy were associated with later clinical features (Drögemüller et al., 2010). Neurological examination may reveal progressive lower motor neuron signs, including progressive ataxia and tetraparesis, delayed proprioceptive paw positioning, distal limb muscle atrophy, hyporeflexia, and inspiratory stridor (high pitched noise during inspiration) (Drögemüller et al., 2010). [IT thanks DVM student Anna Johnston, who provided the basis of this contribution in April 2022.]Defect: yesPathology: In Greyhounds, a mild to marked decrease in the density of myelinated nerve fibres can be observed. A proportion of the remaining nerve fibres may show a “marked to severe loss of circularity due to para- and internodal crenation” and “outfolded myelin loops at paranodes” (Drögemüller et al., 2010). In approximately 10% of the large, myelinated fibres a mild to marked hyperplasia of axon-Schwann cell network can be seen (Drögemüller et al., 2010). Signs of chronic denervation may be present, including neurogenic atrophy present within some skeletal muscles, de-myelination of fibres within intramuscular nerve branches, as well as perimysial lipid accumulation (Drögemüller et al., 2010). A study of affected Alaskan Malamutes found that these dogs demonstrated more than a 70% reduction in expression of the NDRG1 protein. This suggests that affected animals produce insufficient NDRG1 protein levels for the maintenance of the myelin of Schwann cells, thus resulting in this progressive degenerative polyneuropathy (Skedsmo et al., 2021). [IT thanks DVM student Anna Johnston, who provided the basis of this contribution in April 2022.]Prevalence: By genotyping archived samples, Jäderlund et al. (2017) showed that historical and recent phenotypic polyneuropathy cases were carrying the same NDRG1-mutation [c.293GT; p.Gly98Val]. The pedigree analysis showed that all affected Alaskan malamute cases with polyneuropathy could be traced back to one common ancestor of North American origin.
Associated gene(s)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- Gene: Entrez Gene ID 26587068 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
Evidence (references)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- 1997. Idiopathic polyneuropathy in Alaskan Malamutes. J Vet Intern Med — PubMed:PMID9298480 | DOI:10.1111/j.1939-1676.1997.tb00098.x — OMIA Phene_Article / Article
- 2010. A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy. PLoS One — PubMed:PMID20582309 | DOI:10.1371/journal.pone.0011258 — OMIA Phene_Article / Article
- 2009. Hereditary encephalomyelopathy and polyneuropathy in an Alaskan husky. J Small Anim Pract — PubMed:PMID19954445 | DOI:10.1111/j.1748-5827.2009.00857.x — OMIA Phene_Article / Article
- 2012. Hereditary polyneuropathy in the Alaskan Malamute. Tierarztl Prax Ausg K Kleintiere Heimtiere — PubMed:PMID22331326 — OMIA Phene_Article / Article
- 2013. A Gly98Val mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy. PLoS One — PubMed:PMID23393557 | DOI:10.1371/journal.pone.0054547 — OMIA Phene_Article / Article
- 2017. Re-emergence of hereditary polyneuropathy in Scandinavian Alaskan malamute dogs-old enemy or new entity? A case series. Acta Vet Scand — PubMed:PMID28464941 | DOI:10.1186/s13028-017-0295-y — OMIA Phene_Article / Article
- 2021. Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D. Neuromuscul Disord — PubMed:PMID33334662 | DOI:10.1016/j.nmd.2020.11.010 — OMIA Phene_Article / Article
- 2022. Tongue atrophy as a neurological finding in hereditary polyneuropathy in Alaskan malamutes. J Vet Intern Med — PubMed:PMID35019187 | DOI:10.1111/jvim.16351 — OMIA Phene_Article / Article
- 2023. An overview of canine inherited neurological disorders with known causal variants. Animals (Basel) — PubMed:PMID38003185 | DOI:10.3390/ani13223568 — OMIA Phene_Article / Article
Comparative medicine (human OMIM)
Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.
- OMIM:601455 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
- OMIM:605262 (type: gene) — OMIA Group_OMIM (via OMIA_ID)
verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."