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Gordon Setter — Neurological syndrome (hereditary; OMIA-verified breed predisposition)

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--- license: permission_granted topic_id: companion_breed_health_gordon_setter_omia3601_dog category: companion-breed-health title: "Gordon Setter — Neurological syndrome (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/gordon_setter_omia3601_3601.txt date_parsed: 2026-08-02 tokens_estimated: 248 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_gordon_setter_omia3601_dog/01_companion_breed_health_gordon_setter_omia3601_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Gordon Setter — Neurological syndrome (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000720/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Gordon Setter — Neurological syndrome (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: Gordon Setter (Dog)
  • Disorder:
  • Mode of inheritance: Autosomal recessive lethal
  • Clin feat: Yaeger et al. (2000) summarised the diagnostic criteria as: a) early age of onset (3–4 weeks of age), b) characteristic clinical signs (pups exhibit crooked necks and carry heads low, stiffened posture, and staggering gait; appear blind; begin to cry, often incessantly; lose muscle tone and the ability to stand), c) progression to recumbency by 5–6 weeks of age, d) multiple pups generally affected in each litter, e) identification of swollen astrocytes primarily in the cerebellar and cerebrocortical white matter and white matter tracts of the brainstem, f) identification of increased numbers of GFAP-stained astrocyte cytoplasmic processes (this lesion is most readily visualized in the cortical white matter and granular layer of the cerebellum), and g) exclusion of other disease processes.
  • Defect: yes

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 2000. An autosomal recessive, lethal, neurologic disease of Gordon Setter puppies.. J Vet Diagn Invest — PubMed:PMID11108461 | DOI:10.1177/104063870001200615 — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 2000. An autosomal recessive, lethal, neurologic disease of Gordon Setter puppies. J Vet Diagn Invest — PubMed:PMID11108461 | DOI:10.1177/104063870001200615 — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2000. An autosomal recessive, lethal, neurologic disease of Gordon Setter puppies. J Vet Diagn Invest — PubMed:PMID11108461 | DOI:10.1177/104063870001200615 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2000. An autosomal recessive, lethal, neurologic disease of Gordon Setter puppies. J Vet Diagn Invest — PubMed:PMID11108461 | DOI:10.1177/104063870001200615 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 2000. An autosomal recessive, lethal, neurologic disease of Gordon Setter puppies. J Vet Diagn Invest — PubMed:PMID11108461 | DOI:10.1177/104063870001200615 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Sources

Gordon Setter — Neurological syndrome (hereditary; OMIA-verified breed predisposition)
companion-breed-healthPMID 11108461

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