Golden Retriever — Ligneous membranitis (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_golden_retriever_omia3879_dog category: companion-breed-health title: "Golden Retriever — Ligneous membranitis (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/golden_retriever_omia3879_3879.txt date_parsed: 2026-08-02 tokens_estimated: 312 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_golden_retriever_omia3879_dog/01_companion_breed_health_golden_retriever_omia3879_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "Golden Retriever — Ligneous membranitis (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA002020/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

Golden Retriever — Ligneous membranitis (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Breed: Golden Retriever (Dog)
• Disorder:
• Mode of inheritance: Autosomal recessive
• Summary: Ainsworth et al. (2015) Ligneous membranitis (LM) is a rare chronic inflammatory condition of the mucous membranes associated with plasminogen (encoded by PLG) deficiency in affected humans and dogs. ... We identified related Scottish Terriers (littermates) with severe LM and unaffected relatives (sire, dam and a sibling from a previous litter). ... Sequencing of PLG from the affected dogs revealed a homozygous Agt;T single nucleotide polymorphism in an intron donor site (c.1256+2Tgt;A). Turba et al. (2021): LM was diagnosed in a 7-month-old male Maltese dog. The dog was examined for severe recurrent conjunctivitis. A diagnosis of ligneous conjunctivitis was made by an ophthalmologist after a thorough eye examination and was confirmed by a complete lack of plasma activity of plasminogen. The main local signs were redness of the conjunctiva with persistent membranes having ligneous (wood-like) membranes on the eyes. The disease was associated with a complex rearrangement involving the plasminogen gene loci, causing the complete deletion of exon 1.
• Defect: yes

Associated gene(s)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• Gene: Entrez Gene ID 388199107 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene
• OMIA molecular-genetics note: Ainsworth et al. (2015): an A&gt;T SNP in an intron donor site (c.1256+2T&gt;A) Turba et al. (2021): a deletion of 5986 bp involving exon 1 and the flanking region

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 1996. Ligneous conjunctivitis in four Doberman pinschers. J Am Anim Hosp Assoc — PubMed:PMID8875361 | DOI:10.5326/15473317-32-5-439 — OMIA Phene_Article / Article
• 2008. Ligneous conjunctivitis secondary to a congenital plasminogen deficiency in a dog. J Am Vet Med Assoc — PubMed:PMID18312178 | DOI:10.2460/javma.232.5.715 — OMIA Phene_Article / Article
• 1998. The effect of compression ratio and release time on the categorical rating of sound quality. J Acoust Soc Am — PubMed:PMID9604341 | DOI:10.1121/1.422745 — OMIA Phene_Article / Article
• 2016. Features and outcome of a glomerulonephropathy associated with ligneous conjunctivitis in a Doberman pinscher dog. Can Vet J — PubMed:PMID27152037 — OMIA Phene_Article / Article
• 2016. Presentation, clinical pathological and post-mortem findings in three related Scottish terriers with ligneous membranitis. J Small Anim Pract — PubMed:PMID26840763 | DOI:10.1111/jsap.12443 — OMIA Phene_Article / Article
• 2015. Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen (PLG) gene. Anim Genet — PubMed:PMID26360520 | DOI:10.1111/age.12339 — OMIA Phene_Article / Article
• 2012. Genetics of ligneous membranitis in a family of Scottish terriers. J Small Anim Pract — PubMed:PMID23898908 | DOI:10.1111/j.1748-5827.2012.01309.x — OMIA Phene_Article / Article
• 2012. Ligneous membranitis in Scottish terriers. Vet Rec — PubMed:PMID22890402 | DOI:10.1136/vr.e5382 — OMIA Phene_Article / Article
• 2009. Ligneous conjunctivitis in a plasminogen-deficient dog: clinical management and 2-year follow-up. Vet Ophthalmol — PubMed:PMID19604341 | DOI:10.1111/j.1463-5224.2009.00700.x — OMIA Phene_Article / Article
• 2021. A large deletion in the plasminogen gene is associated with ligneous membranitis in a Maltese dog. Anim Genet — PubMed:PMID34370320 | DOI:10.1111/age.13130 — OMIA Phene_Article / Article
• 2022. Genetics of inherited skin disorders in dogs. Vet J — PubMed:PMID34861369 | DOI:10.1016/j.tvjl.2021.105782 — OMIA Phene_Article / Article
• 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• OMIM:217090 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
• OMIM:173350 (type: gene) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."