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German Wirehaired Pointer — Corneal dystrophy (hereditary; OMIA-verified breed predisposition)

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--- license: permission_granted topic_id: companion_breed_health_german_wirehaired_pointer_omia458_dog category: companion-breed-health title: "German Wirehaired Pointer — Corneal dystrophy (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/german_wirehaired_pointer_omia458_458.txt date_parsed: 2026-08-02 tokens_estimated: 131 verification: method: substring_match claims: 4 passed: 4 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_german_wirehaired_pointer_omia458_dog/01_companion_breed_health_german_wirehaired_pointer_omia458_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "German Wirehaired Pointer — Corneal dystrophy (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000230/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

German Wirehaired Pointer — Corneal dystrophy (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: German Wirehaired Pointer (Dog)
  • Disorder:
  • Summary: Genetics Committee of the American College of Veterinary Opthalmologists (2021): non-inflammatory corneal opacity (white to gray) present in one or more of the corneal layers (epithelium, stroma, endothelium). The term dystrophy implies an inherited condition. It is usually bilateral although not necessarily symmetrical and the onset in one eye may precede the other.
  • Defect: yes

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1990. Corneal dystrophy in the dog and cat.. Veterinary Clinics of North America-Small Animal Practice — OMIA Phene_Article / Article
  • 2018. Phenotypic characterization of corneal endothelial dystrophy in German Shorthaired and Wirehaired Pointers using in vivo advanced corneal imaging and histopathology.. Cornea — PubMed:PMID29077583 | DOI:10.1097/ICO.0000000000001431 — OMIA Phene_Article / Article
  • 2020. Corneal dystrophy in Dutch Belted rabbits as a possible model of Thiel-Behnke subtype of epithelial-stromal TGFβ-induced corneal dystrophy.. Toxicol Pathol — PubMed:PMID33287658 | DOI:10.1177/0192623320968092 — OMIA Phene_Article / Article
  • 1988. Crystalline corneal dystrophy in the dog. Histochemical and ultrastructural study.. Cornea — PubMed:PMID3261227 | DOI:10.1097/00003226-198802000-00011 — OMIA Phene_Article / Article
  • 1981. Oval corneal opacities in Beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia.. Invest Ophthalmol Vis Sci — PubMed:PMID7251305 — OMIA Phene_Article / Article
  • 1982. Oval lipid corneal opacities in Beagles: V. Ultrastructure.. Veterinary Pathology — OMIA Phene_Article / Article
  • 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article
  • 2022. A multicenter retrospective evaluation of the prevalence of known and presumed hereditary eye diseases in Lagotto Romagnolo dog breed within a referral population in Italy (2012-2020).. Vet Ophthalmol — PubMed:PMID35976615 | DOI:10.1111/vop.13020 — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1990. Corneal dystrophy in the dog and cat. Veterinary Clinics of North America-Small Animal Practice — OMIA Phene_Article / Article
  • 2018. Phenotypic characterization of corneal endothelial dystrophy in German Shorthaired and Wirehaired Pointers using in vivo advanced corneal imaging and histopathology. Cornea — PubMed:PMID29077583 | DOI:10.1097/ICO.0000000000001431 — OMIA Phene_Article / Article
  • 2020. Corneal dystrophy in Dutch Belted rabbits as a possible model of Thiel-Behnke subtype of epithelial-stromal TGFβ-induced corneal dystrophy. Toxicol Pathol — PubMed:PMID33287658 | DOI:10.1177/0192623320968092 — OMIA Phene_Article / Article
  • 1988. Crystalline corneal dystrophy in the dog. Histochemical and ultrastructural study. Cornea — PubMed:PMID3261227 | DOI:10.1097/00003226-198802000-00011 — OMIA Phene_Article / Article
  • 1981. Oval corneal opacities in Beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia. Invest Ophthalmol Vis Sci — PubMed:PMID7251305 — OMIA Phene_Article / Article
  • 1982. Oval lipid corneal opacities in Beagles: V. Ultrastructure. Veterinary Pathology — OMIA Phene_Article / Article
  • 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article
  • 2022. A multicenter retrospective evaluation of the prevalence of known and presumed hereditary eye diseases in Lagotto Romagnolo dog breed within a referral population in Italy (2012-2020). Vet Ophthalmol — PubMed:PMID35976615 | DOI:10.1111/vop.13020 — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1990. Corneal dystrophy in the dog and cat. Veterinary Clinics of North America-Small Animal Practice — OMIA Phene_Article / Article
  • 2018. Phenotypic characterization of corneal endothelial dystrophy in German Shorthaired and Wirehaired Pointers using in vivo advanced corneal imaging and histopathology. Cornea — PubMed:PMID29077583 | DOI:10.1097/ICO.0000000000001431 — OMIA Phene_Article / Article
  • 2020. Corneal dystrophy in Dutch Belted rabbits as a possible model of Thiel-Behnke subtype of epithelial-stromal TGFβ-induced corneal dystrophy. Toxicol Pathol — PubMed:PMID33287658 | DOI:10.1177/0192623320968092 — OMIA Phene_Article / Article
  • 1988. Crystalline corneal dystrophy in the dog. Histochemical and ultrastructural study. Cornea — PubMed:PMID3261227 | DOI:10.1097/00003226-198802000-00011 — OMIA Phene_Article / Article
  • 1981. Oval corneal opacities in Beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia. Invest Ophthalmol Vis Sci — PubMed:PMID7251305 — OMIA Phene_Article / Article
  • 1982. Oval lipid corneal opacities in Beagles: V. Ultrastructure. Veterinary Pathology — OMIA Phene_Article / Article
  • 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article
  • 2022. A multicenter retrospective evaluation of the prevalence of known and presumed hereditary eye diseases in Lagotto Romagnolo dog breed within a referral population in Italy (2012-2020). Vet Ophthalmol — PubMed:PMID35976615 | DOI:10.1111/vop.13020 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1990. Corneal dystrophy in the dog and cat. Veterinary Clinics of North America-Small Animal Practice — OMIA Phene_Article / Article
  • 2018. Phenotypic characterization of corneal endothelial dystrophy in German Shorthaired and Wirehaired Pointers using in vivo advanced corneal imaging and histopathology. Cornea — PubMed:PMID29077583 | DOI:10.1097/ICO.0000000000001431 — OMIA Phene_Article / Article
  • 2020. Corneal dystrophy in Dutch Belted rabbits as a possible model of Thiel-Behnke subtype of epithelial-stromal TGFβ-induced corneal dystrophy. Toxicol Pathol — PubMed:PMID33287658 | DOI:10.1177/0192623320968092 — OMIA Phene_Article / Article
  • 1988. Crystalline corneal dystrophy in the dog. Histochemical and ultrastructural study. Cornea — PubMed:PMID3261227 | DOI:10.1097/00003226-198802000-00011 — OMIA Phene_Article / Article
  • 1981. Oval corneal opacities in Beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia. Invest Ophthalmol Vis Sci — PubMed:PMID7251305 — OMIA Phene_Article / Article
  • 1982. Oval lipid corneal opacities in Beagles: V. Ultrastructure. Veterinary Pathology — OMIA Phene_Article / Article
  • 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article
  • 2022. A multicenter retrospective evaluation of the prevalence of known and presumed hereditary eye diseases in Lagotto Romagnolo dog breed within a referral population in Italy (2012-2020). Vet Ophthalmol — PubMed:PMID35976615 | DOI:10.1111/vop.13020 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1990. Corneal dystrophy in the dog and cat. Veterinary Clinics of North America-Small Animal Practice — OMIA Phene_Article / Article
  • 2018. Phenotypic characterization of corneal endothelial dystrophy in German Shorthaired and Wirehaired Pointers using in vivo advanced corneal imaging and histopathology. Cornea — PubMed:PMID29077583 | DOI:10.1097/ICO.0000000000001431 — OMIA Phene_Article / Article
  • 2020. Corneal dystrophy in Dutch Belted rabbits as a possible model of Thiel-Behnke subtype of epithelial-stromal TGFβ-induced corneal dystrophy. Toxicol Pathol — PubMed:PMID33287658 | DOI:10.1177/0192623320968092 — OMIA Phene_Article / Article
  • 1988. Crystalline corneal dystrophy in the dog. Histochemical and ultrastructural study. Cornea — PubMed:PMID3261227 | DOI:10.1097/00003226-198802000-00011 — OMIA Phene_Article / Article
  • 1981. Oval corneal opacities in Beagles. III. Histochemical demonstration of stromal lipids without hyperlipidemia. Invest Ophthalmol Vis Sci — PubMed:PMID7251305 — OMIA Phene_Article / Article
  • 1982. Oval lipid corneal opacities in Beagles: V. Ultrastructure. Veterinary Pathology — OMIA Phene_Article / Article
  • 2021. The Blue Book: Ocular disorders presumed to be inherited in purebred dogs. 13th Edition. https://ofa.org/wp-content/uploads/2022/10/ACVO-Blue-Book-2021.pdf — OMIA Phene_Article / Article
  • 2022. A multicenter retrospective evaluation of the prevalence of known and presumed hereditary eye diseases in Lagotto Romagnolo dog breed within a referral population in Italy (2012-2020). Vet Ophthalmol — PubMed:PMID35976615 | DOI:10.1111/vop.13020 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Sources

German Wirehaired Pointer — Corneal dystrophy (hereditary; OMIA-verified breed predisposition)
companion-breed-healthPMID 29077583

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