German Shepherd Dog — Shaking puppy syndrome (hereditary; OMIA-verified breed predisposition)

--- license: permission_granted topic_id: companion_breed_health_german_shepherd_dog_shaking_puppy_syndrome_dog category: companion-breed-health title: "German Shepherd Dog — Shaking puppy syndrome (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/german_shepherd_dog_shaking_puppy_syndrome_4474.txt date_parsed: 2026-08-02 tokens_estimated: 157 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_german_shepherd_dog_shaking_puppy_syndrome_dog/01_companion_breed_health_german_shepherd_dog_shaking_puppy_syndrome_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "German Shepherd Dog — Shaking puppy syndrome (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA002321/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

German Shepherd Dog — Shaking puppy syndrome (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

• Breed: German Shepherd Dog (Dog)
• Disorder: Shaking puppy syndrome
• Mode of inheritance: Autosomal recessive
• Summary: Quitt et al. (2021) described a novel hypomyelinating leukodystrophy in 11 related German Shepherd dogs. The clinical course was nonprogressive and adult dogs walked with residual pelvic limb ataxia. Repeated conventional brain MRI was useful to characterize abnormal maturation of subcortical and cerebellar white matter. The disease is thought to be genetic in origin with an autosomal recessive mode of inheritance.
• Defect: yes

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

• 2021. A hypomyelinating leukodystrophy in German Shepherd dogs.. J Vet Intern Med — PubMed:PMID33734486 | DOI:10.1111/jvim.16085 — OMIA Phene_Article / Article
• 2024. Congenital spongiform leukodystrophy in 2 female littermate German shepherd puppies.. J Vet Intern Med — PubMed:PMID38544400 | DOI:10.1111/jvim.17055 — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

• 2021. A hypomyelinating leukodystrophy in German Shepherd dogs. J Vet Intern Med — PubMed:PMID33734486 | DOI:10.1111/jvim.16085 — OMIA Phene_Article / Article
• 2024. Congenital spongiform leukodystrophy in 2 female littermate German shepherd puppies. J Vet Intern Med — PubMed:PMID38544400 | DOI:10.1111/jvim.17055 — OMIA Phene_Article / Article

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 2021. A hypomyelinating leukodystrophy in German Shepherd dogs. J Vet Intern Med — PubMed:PMID33734486 | DOI:10.1111/jvim.16085 — OMIA Phene_Article / Article
• 2024. Congenital spongiform leukodystrophy in 2 female littermate German shepherd puppies. J Vet Intern Med — PubMed:PMID38544400 | DOI:10.1111/jvim.17055 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 2021. A hypomyelinating leukodystrophy in German Shepherd dogs. J Vet Intern Med — PubMed:PMID33734486 | DOI:10.1111/jvim.16085 — OMIA Phene_Article / Article
• 2024. Congenital spongiform leukodystrophy in 2 female littermate German shepherd puppies. J Vet Intern Med — PubMed:PMID38544400 | DOI:10.1111/jvim.17055 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

• 2021. A hypomyelinating leukodystrophy in German Shepherd dogs. J Vet Intern Med — PubMed:PMID33734486 | DOI:10.1111/jvim.16085 — OMIA Phene_Article / Article
• 2024. Congenital spongiform leukodystrophy in 2 female littermate German shepherd puppies. J Vet Intern Med — PubMed:PMID38544400 | DOI:10.1111/jvim.17055 — OMIA Phene_Article / Article

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."