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German Shepherd Dog — German Shepherd dog pyoderma (hereditary; OMIA-verified breed predisposition)

companion_breed_health_german_shepherd_dog_german_shepherd_dog_pyoderma_dog

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--- license: permission_granted topic_id: companion_breed_health_german_shepherd_dog_german_shepherd_dog_pyoderma_dog category: companion-breed-health title: "German Shepherd Dog — German Shepherd dog pyoderma (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/german_shepherd_dog_german_shepherd_dog_pyoderma_3639.txt date_parsed: 2026-08-02 tokens_estimated: 409 verification: method: substring_match claims: 5 passed: 5 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_german_shepherd_dog_german_shepherd_dog_pyoderma_dog/01_companion_breed_health_german_shepherd_dog_german_shepherd_dog_pyoderma_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "German Shepherd Dog — German Shepherd dog pyoderma (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA001877/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

German Shepherd Dog — German Shepherd dog pyoderma (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: German Shepherd Dog (Dog)
  • Disorder: German Shepherd dog pyoderma
  • `Mode of inheritance: Wisselink et al. (1989) presented pedigree data and claimed autosomal recessive inheritance, but did not actually conduct a segregation analysis.

Rosser (2006): Although dogs with GSP may have clinically similar presentations, the underlying causes of the disease process can be multifactorial in etiology. ... [P]urebred German Shepherd Dogs are predisposed to the development of this disease, but it is important to note that a similar condition may occur in German Shepherd crossbred dogs and other herding breeds of dogs ...`

  • Clin feat: Rosser (2006): The most common lesion initially observed in cases of GSP is clinically similar to that of a “hot spot” and is usually first noticed in the lumbosacral region, lateral hip, or lateral thigh region ... . As the disease progresses, several additional lesions may be observed, including areas of posttraumatic alopecia, hyperpigmentation, papules, pustules, hemorrhagic bullae, ulcers, crusts, and draining tracts (usually with a hemopurulent discharge) with surrounding friable tissue. The disease ultimately takes on the appearance of chronic deep pyoderma or cellulitis, and there is frequently an associated regional lymphadenopathy. Less commonly observed clinical signs may include a purulent otitis externa, perianal fistulas, focal metatarsal fistulas (sterile pedal panniculitis), and fever with signs of systemic illness [Denerolle et al., 1998; Rosser 1997; Ihrke DeManuelle, 1999].
  • Defect: yes

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1988. Immunologic aspects of German shepherd dog pyoderma (GSP).. Vet Immunol Immunopathol — PubMed:PMID3176335 | DOI:10.1016/0165-2427(88)90047-5 — OMIA Phene_Article / Article
  • 1989. German shepherd dog pyoderma: a genetic disorder.. Vet Q — PubMed:PMID2781707 | DOI:10.1080/01652176.1989.9694215 — OMIA Phene_Article / Article
  • 1990. Investigations on the role of flea antigen in the pathogenesis of German shepherd dog pyoderma (GSP).. Vet Q — PubMed:PMID2321348 | DOI:10.1080/01652176.1990.9694237 — OMIA Phene_Article / Article
  • 1990. Investigations on the role of staphylococci in the pathogenesis of German shepherd dog pyoderma (GSP).. Vet Q — PubMed:PMID2321349 | DOI:10.1080/01652176.1990.9694238 — OMIA Phene_Article / Article
  • 1994. An immunopathological study of deep pyoderma in the dog.. Res Vet Sci — PubMed:PMID8146448 | DOI:10.1016/0034-5288(94)90190-2 — OMIA Phene_Article / Article
  • 1995. Tissue immunoglobulin G subclasses observed in immune-mediated dermatopathy, deep pyoderma and hypersensitivity dermatitis in dogs.. Res Vet Sci — PubMed:PMID7709067 | DOI:10.1016/0034-5288(95)90094-2 — OMIA Phene_Article / Article
  • 1995. Lymphocyte subset abnormalities in German shepherd dog pyoderma (GSP).. Vet Immunol Immunopathol — PubMed:PMID8746694 | DOI:10.1016/0165-2427(95)05463-4 — OMIA Phene_Article / Article
  • 1997. German shepherd dog pyoderma: a prospective study of 12 dogs.. J Am Anim Hosp Assoc — PubMed:PMID9204474 | DOI:10.5326/15473317-33-4-355 — OMIA Phene_Article / Article
  • 1997. Aspects of the humoral immune response to Staphylococcus intermedius in dogs with superficial pyoderma, deep pyoderma and anal furunculosis.. Vet Immunol Immunopathol — PubMed:PMID9336879 | DOI:10.1016/s0165-2427(97)00029-9 — OMIA Phene_Article / Article
  • 2004. Antibiotic responsive ulcerative dermatoses in German Shepherd Dogs with mucocutaneous pyoderma.. Aust Vet J — PubMed:PMID15359964 | DOI:10.1111/j.1751-0813.2004.tb11165.x — OMIA Phene_Article / Article
  • 2006. German Shepherd Dog pyoderma.. Vet Clin North Am Small Anim Pract — PubMed:PMID16364785 | DOI:10.1016/j.cvsm.2005.09.008 — OMIA Phene_Article / Article
  • 2014. Azithromycin pharmacokinetics in the serum and its distribution to the skin in healthy dogs and dogs with pyoderma.. Vet J — PubMed:PMID24472431 | DOI:10.1016/j.tvjl.2013.12.022 — OMIA Phene_Article / Article
  • (8 additional references in OMIA)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1988. Immunologic aspects of German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol — PubMed:PMID3176335 | DOI:10.1016/0165-2427(88)90047-5 — OMIA Phene_Article / Article
  • 1989. German shepherd dog pyoderma: a genetic disorder. Vet Q — PubMed:PMID2781707 | DOI:10.1080/01652176.1989.9694215 — OMIA Phene_Article / Article
  • 1990. Investigations on the role of flea antigen in the pathogenesis of German shepherd dog pyoderma (GSP). Vet Q — PubMed:PMID2321348 | DOI:10.1080/01652176.1990.9694237 — OMIA Phene_Article / Article
  • 1990. Investigations on the role of staphylococci in the pathogenesis of German shepherd dog pyoderma (GSP). Vet Q — PubMed:PMID2321349 | DOI:10.1080/01652176.1990.9694238 — OMIA Phene_Article / Article
  • 1994. An immunopathological study of deep pyoderma in the dog. Res Vet Sci — PubMed:PMID8146448 | DOI:10.1016/0034-5288(94)90190-2 — OMIA Phene_Article / Article
  • 1995. Tissue immunoglobulin G subclasses observed in immune-mediated dermatopathy, deep pyoderma and hypersensitivity dermatitis in dogs. Res Vet Sci — PubMed:PMID7709067 | DOI:10.1016/0034-5288(95)90094-2 — OMIA Phene_Article / Article
  • 1995. Lymphocyte subset abnormalities in German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol — PubMed:PMID8746694 | DOI:10.1016/0165-2427(95)05463-4 — OMIA Phene_Article / Article
  • 1997. German shepherd dog pyoderma: a prospective study of 12 dogs. J Am Anim Hosp Assoc — PubMed:PMID9204474 | DOI:10.5326/15473317-33-4-355 — OMIA Phene_Article / Article
  • 1997. Aspects of the humoral immune response to Staphylococcus intermedius in dogs with superficial pyoderma, deep pyoderma and anal furunculosis. Vet Immunol Immunopathol — PubMed:PMID9336879 | DOI:10.1016/s0165-2427(97)00029-9 — OMIA Phene_Article / Article
  • 2004. Antibiotic responsive ulcerative dermatoses in German Shepherd Dogs with mucocutaneous pyoderma. Aust Vet J — PubMed:PMID15359964 | DOI:10.1111/j.1751-0813.2004.tb11165.x — OMIA Phene_Article / Article
  • 2006. German Shepherd Dog pyoderma. Vet Clin North Am Small Anim Pract — PubMed:PMID16364785 | DOI:10.1016/j.cvsm.2005.09.008 — OMIA Phene_Article / Article
  • 2014. Azithromycin pharmacokinetics in the serum and its distribution to the skin in healthy dogs and dogs with pyoderma. Vet J — PubMed:PMID24472431 | DOI:10.1016/j.tvjl.2013.12.022 — OMIA Phene_Article / Article
  • (8 additional references in OMIA)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1988. Immunologic aspects of German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol — PubMed:PMID3176335 | DOI:10.1016/0165-2427(88)90047-5 — OMIA Phene_Article / Article
  • 1989. German shepherd dog pyoderma: a genetic disorder. Vet Q — PubMed:PMID2781707 | DOI:10.1080/01652176.1989.9694215 — OMIA Phene_Article / Article
  • 1990. Investigations on the role of flea antigen in the pathogenesis of German shepherd dog pyoderma (GSP). Vet Q — PubMed:PMID2321348 | DOI:10.1080/01652176.1990.9694237 — OMIA Phene_Article / Article
  • 1990. Investigations on the role of staphylococci in the pathogenesis of German shepherd dog pyoderma (GSP). Vet Q — PubMed:PMID2321349 | DOI:10.1080/01652176.1990.9694238 — OMIA Phene_Article / Article
  • 1994. An immunopathological study of deep pyoderma in the dog. Res Vet Sci — PubMed:PMID8146448 | DOI:10.1016/0034-5288(94)90190-2 — OMIA Phene_Article / Article
  • 1995. Tissue immunoglobulin G subclasses observed in immune-mediated dermatopathy, deep pyoderma and hypersensitivity dermatitis in dogs. Res Vet Sci — PubMed:PMID7709067 | DOI:10.1016/0034-5288(95)90094-2 — OMIA Phene_Article / Article
  • 1995. Lymphocyte subset abnormalities in German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol — PubMed:PMID8746694 | DOI:10.1016/0165-2427(95)05463-4 — OMIA Phene_Article / Article
  • 1997. German shepherd dog pyoderma: a prospective study of 12 dogs. J Am Anim Hosp Assoc — PubMed:PMID9204474 | DOI:10.5326/15473317-33-4-355 — OMIA Phene_Article / Article
  • 1997. Aspects of the humoral immune response to Staphylococcus intermedius in dogs with superficial pyoderma, deep pyoderma and anal furunculosis. Vet Immunol Immunopathol — PubMed:PMID9336879 | DOI:10.1016/s0165-2427(97)00029-9 — OMIA Phene_Article / Article
  • 2004. Antibiotic responsive ulcerative dermatoses in German Shepherd Dogs with mucocutaneous pyoderma. Aust Vet J — PubMed:PMID15359964 | DOI:10.1111/j.1751-0813.2004.tb11165.x — OMIA Phene_Article / Article
  • 2006. German Shepherd Dog pyoderma. Vet Clin North Am Small Anim Pract — PubMed:PMID16364785 | DOI:10.1016/j.cvsm.2005.09.008 — OMIA Phene_Article / Article
  • 2014. Azithromycin pharmacokinetics in the serum and its distribution to the skin in healthy dogs and dogs with pyoderma. Vet J — PubMed:PMID24472431 | DOI:10.1016/j.tvjl.2013.12.022 — OMIA Phene_Article / Article
  • (8 additional references in OMIA)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1988. Immunologic aspects of German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol — PubMed:PMID3176335 | DOI:10.1016/0165-2427(88)90047-5 — OMIA Phene_Article / Article
  • 1989. German shepherd dog pyoderma: a genetic disorder. Vet Q — PubMed:PMID2781707 | DOI:10.1080/01652176.1989.9694215 — OMIA Phene_Article / Article
  • 1990. Investigations on the role of flea antigen in the pathogenesis of German shepherd dog pyoderma (GSP). Vet Q — PubMed:PMID2321348 | DOI:10.1080/01652176.1990.9694237 — OMIA Phene_Article / Article
  • 1990. Investigations on the role of staphylococci in the pathogenesis of German shepherd dog pyoderma (GSP). Vet Q — PubMed:PMID2321349 | DOI:10.1080/01652176.1990.9694238 — OMIA Phene_Article / Article
  • 1994. An immunopathological study of deep pyoderma in the dog. Res Vet Sci — PubMed:PMID8146448 | DOI:10.1016/0034-5288(94)90190-2 — OMIA Phene_Article / Article
  • 1995. Tissue immunoglobulin G subclasses observed in immune-mediated dermatopathy, deep pyoderma and hypersensitivity dermatitis in dogs. Res Vet Sci — PubMed:PMID7709067 | DOI:10.1016/0034-5288(95)90094-2 — OMIA Phene_Article / Article
  • 1995. Lymphocyte subset abnormalities in German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol — PubMed:PMID8746694 | DOI:10.1016/0165-2427(95)05463-4 — OMIA Phene_Article / Article
  • 1997. German shepherd dog pyoderma: a prospective study of 12 dogs. J Am Anim Hosp Assoc — PubMed:PMID9204474 | DOI:10.5326/15473317-33-4-355 — OMIA Phene_Article / Article
  • 1997. Aspects of the humoral immune response to Staphylococcus intermedius in dogs with superficial pyoderma, deep pyoderma and anal furunculosis. Vet Immunol Immunopathol — PubMed:PMID9336879 | DOI:10.1016/s0165-2427(97)00029-9 — OMIA Phene_Article / Article
  • 2004. Antibiotic responsive ulcerative dermatoses in German Shepherd Dogs with mucocutaneous pyoderma. Aust Vet J — PubMed:PMID15359964 | DOI:10.1111/j.1751-0813.2004.tb11165.x — OMIA Phene_Article / Article
  • 2006. German Shepherd Dog pyoderma. Vet Clin North Am Small Anim Pract — PubMed:PMID16364785 | DOI:10.1016/j.cvsm.2005.09.008 — OMIA Phene_Article / Article
  • 2014. Azithromycin pharmacokinetics in the serum and its distribution to the skin in healthy dogs and dogs with pyoderma. Vet J — PubMed:PMID24472431 | DOI:10.1016/j.tvjl.2013.12.022 — OMIA Phene_Article / Article
  • (8 additional references in OMIA)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1988. Immunologic aspects of German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol — PubMed:PMID3176335 | DOI:10.1016/0165-2427(88)90047-5 — OMIA Phene_Article / Article
  • 1989. German shepherd dog pyoderma: a genetic disorder. Vet Q — PubMed:PMID2781707 | DOI:10.1080/01652176.1989.9694215 — OMIA Phene_Article / Article
  • 1990. Investigations on the role of flea antigen in the pathogenesis of German shepherd dog pyoderma (GSP). Vet Q — PubMed:PMID2321348 | DOI:10.1080/01652176.1990.9694237 — OMIA Phene_Article / Article
  • 1990. Investigations on the role of staphylococci in the pathogenesis of German shepherd dog pyoderma (GSP). Vet Q — PubMed:PMID2321349 | DOI:10.1080/01652176.1990.9694238 — OMIA Phene_Article / Article
  • 1994. An immunopathological study of deep pyoderma in the dog. Res Vet Sci — PubMed:PMID8146448 | DOI:10.1016/0034-5288(94)90190-2 — OMIA Phene_Article / Article
  • 1995. Tissue immunoglobulin G subclasses observed in immune-mediated dermatopathy, deep pyoderma and hypersensitivity dermatitis in dogs. Res Vet Sci — PubMed:PMID7709067 | DOI:10.1016/0034-5288(95)90094-2 — OMIA Phene_Article / Article
  • 1995. Lymphocyte subset abnormalities in German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol — PubMed:PMID8746694 | DOI:10.1016/0165-2427(95)05463-4 — OMIA Phene_Article / Article
  • 1997. German shepherd dog pyoderma: a prospective study of 12 dogs. J Am Anim Hosp Assoc — PubMed:PMID9204474 | DOI:10.5326/15473317-33-4-355 — OMIA Phene_Article / Article
  • 1997. Aspects of the humoral immune response to Staphylococcus intermedius in dogs with superficial pyoderma, deep pyoderma and anal furunculosis. Vet Immunol Immunopathol — PubMed:PMID9336879 | DOI:10.1016/s0165-2427(97)00029-9 — OMIA Phene_Article / Article
  • 2004. Antibiotic responsive ulcerative dermatoses in German Shepherd Dogs with mucocutaneous pyoderma. Aust Vet J — PubMed:PMID15359964 | DOI:10.1111/j.1751-0813.2004.tb11165.x — OMIA Phene_Article / Article
  • 2006. German Shepherd Dog pyoderma. Vet Clin North Am Small Anim Pract — PubMed:PMID16364785 | DOI:10.1016/j.cvsm.2005.09.008 — OMIA Phene_Article / Article
  • 2014. Azithromycin pharmacokinetics in the serum and its distribution to the skin in healthy dogs and dogs with pyoderma. Vet J — PubMed:PMID24472431 | DOI:10.1016/j.tvjl.2013.12.022 — OMIA Phene_Article / Article
  • (8 additional references in OMIA)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Sources

German Shepherd Dog — German Shepherd dog pyoderma (hereditary; OMIA-verified breed predisposition)
companion-breed-healthPMID 3176335

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