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German Shepherd Dog — Canine atopic dermatitis (CAD) (hereditary; OMIA-verified breed predisposition)

companion_breed_health_german_shepherd_dog_canine_atopic_dermatitis_cad_dog

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--- license: permission_granted topic_id: companion_breed_health_german_shepherd_dog_canine_atopic_dermatitis_cad_dog category: companion-breed-health title: "German Shepherd Dog — Canine atopic dermatitis (CAD) (hereditary; OMIA-verified breed predisposition)" lang: en source: "OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump." source_file: pdf-raw/breed-health/german_shepherd_dog_canine_atopic_dermatitis_cad_512.txt date_parsed: 2026-08-02 tokens_estimated: 347 verification: method: substring_match claims: 6 passed: 6 date: 2026-08-02 recovered: false path: companion-breed-health/companion_breed_health_german_shepherd_dog_canine_atopic_dermatitis_cad_dog/01_companion_breed_health_german_shepherd_dog_canine_atopic_dermatitis_cad_dog.md source_document: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" citation: authority: "OMIA — Online Mendelian Inheritance in Animals (University of Sydney)" title: "German Shepherd Dog — Canine atopic dermatitis (CAD) (hereditary; OMIA-verified breed predisposition)" url: "https://omia.org/OMIA000269/9615/" retrieved: "2026-08-02" ref: "OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70" doc_type: "academic animal-genetics database (breed-specific disorder entries)" needs_review: false

German Shepherd Dog — Canine atopic dermatitis (CAD) (hereditary; OMIA-verified breed predisposition)

Source: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; every claim below is a C1 byte-substring of it.

Claims

  • Breed: German Shepherd Dog (Dog)
  • Disorder: Canine atopic dermatitis (CAD)
  • Mode of inheritance: Multifactorial
  • Clin feat: Clinical and other issues relating to this disorder were comprehensively covered in an extensive series of papers published in Veterinary Immunology and Immunopathology in 2001 (all included in the references below) by the ACVD task force on canine atopic dermatitis.
  • Defect: yes
  • Prevalence: From an anlysis of Case records (n = 23,000) from [the] University [of Sydney] Veterinary Teaching Hospital (UVTH) dogs, including 722 with CAD compared with 13 previous studies, Mazrier et al. (2016) reported that Eleven dog breeds with significant increased OR (≥1.0) were identified; all with breed CAD cases proportionally higher than their base hospital population. Gender risk in males from the pug dog breed (P = 0.007) was detected and the bichon frise breed had a similar trend (P = 0.05). Sixteen predisposed dog breeds were identified by systematic review. All breeds with significant increased OR in UVTH had ADRPR gt; 1.4; five (boxer, bulldog, Labrador retriever, pug, West Highland white terrier) were recognized as predisposed worldwide. One clade of breeds with common ancestry was highly represented in CAD cases worldwide and in Australia (81% of the significant OR cases).

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1994. 207 Intracutaneous Tests in Dogs with Suspicion of Atopic Dermatitis. Kleintierpraxis — OMIA Phene_Article / Article
  • 1996. Langerhans cell hyperplasia and ige expression in canine atopic dermatitis. Archives of Dermatological Research — PubMed:PMID8919040 — OMIA Phene_Article / Article
  • 1997. Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. American Journal of Dermatopathology — PubMed:PMID9335242 — OMIA Phene_Article / Article
  • 1997. Serum and skin IgA concentrations in normal and atopic dogs. Aust Vet J — PubMed:PMID9469228 | DOI:10.1111/j.1751-0813.1997.tb11264.x — OMIA Phene_Article / Article
  • 1998. Canine atopic dermatitis - pathomechanisms and comparison of ict and elisa with monoclonal anti-ige-antibody [German]. Praktische Tierarzt — OMIA Phene_Article / Article
  • 1998. Reevaluation of diagnostic criteria of canine atopic dermatitis [French]. Revue de Medecine Veterinaire — OMIA Phene_Article / Article
  • 1999. Serum immunoglobulin E concentrations in West Highland White Terrier puppies do not predict development of atopic dermatitis. Veterinary Dermatology — OMIA Phene_Article / Article
  • 1999. Comparison of intradermal testing and serum testing for allergen-specific IgE using monoclonal IgE antibodies in 84 atopic dogs. Aust Vet J — PubMed:PMID10376096 | DOI:10.1111/j.1751-0813.1999.tb10263.x — OMIA Phene_Article / Article
  • 2000. Adherence by Staphylococcus intermedius to canine keratinocytes in atopic dermatitis. Research in Veterinary Science — PubMed:PMID10877976 | DOI:10.1053/rvsc.2000.0378 — OMIA Phene_Article / Article
  • 2000. IgE-reactivity to major Japanese cedar (Cryptomeria japonica) pollen allergens (Cry j 1 and Cry j 2) by ELISA in dogs with atopic dermatitis. Veterinary Immunology & Immunopathology — OMIA Phene_Article / Article
  • 2000. Aero-allergens in canine atopic dermatitis in southeastern Australia based on 1000 intradermal skin tests. Australian Veterinary Journal — PubMed:PMID10920777 — OMIA Phene_Article / Article
  • 2001. Peripheral blood mononuclear cell responses to Dermatophagogoides farinae in canine atopic dermatitis. Veterinary Immunology & Immunopathology — OMIA Phene_Article / Article
  • (204 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:603165 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605803 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605804 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605805 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605844 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605845 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613064 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613518 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613519 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.

  • 1994. 207 Intracutaneous Tests in Dogs with Suspicion of Atopic Dermatitis. Kleintierpraxis — OMIA Phene_Article / Article
  • 1996. Langerhans cell hyperplasia and ige expression in canine atopic dermatitis. Archives of Dermatological Research — PubMed:PMID8919040 — OMIA Phene_Article / Article
  • 1997. Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. American Journal of Dermatopathology — PubMed:PMID9335242 — OMIA Phene_Article / Article
  • 1997. Serum and skin IgA concentrations in normal and atopic dogs. Aust Vet J — PubMed:PMID9469228 | DOI:10.1111/j.1751-0813.1997.tb11264.x — OMIA Phene_Article / Article
  • 1998. Canine atopic dermatitis - pathomechanisms and comparison of ict and elisa with monoclonal anti-ige-antibody [German]. Praktische Tierarzt — OMIA Phene_Article / Article
  • 1998. Reevaluation of diagnostic criteria of canine atopic dermatitis [French]. Revue de Medecine Veterinaire — OMIA Phene_Article / Article
  • 1999. Serum immunoglobulin E concentrations in West Highland White Terrier puppies do not predict development of atopic dermatitis. Veterinary Dermatology — OMIA Phene_Article / Article
  • 1999. Comparison of intradermal testing and serum testing for allergen-specific IgE using monoclonal IgE antibodies in 84 atopic dogs. Aust Vet J — PubMed:PMID10376096 | DOI:10.1111/j.1751-0813.1999.tb10263.x — OMIA Phene_Article / Article
  • 2000. Adherence by Staphylococcus intermedius to canine keratinocytes in atopic dermatitis. Research in Veterinary Science — PubMed:PMID10877976 | DOI:10.1053/rvsc.2000.0378 — OMIA Phene_Article / Article
  • 2000. IgE-reactivity to major Japanese cedar (Cryptomeria japonica) pollen allergens (Cry j 1 and Cry j 2) by ELISA in dogs with atopic dermatitis. Veterinary Immunology & Immunopathology — OMIA Phene_Article / Article
  • 2000. Aero-allergens in canine atopic dermatitis in southeastern Australia based on 1000 intradermal skin tests. Australian Veterinary Journal — PubMed:PMID10920777 — OMIA Phene_Article / Article
  • 2001. Peripheral blood mononuclear cell responses to Dermatophagogoides farinae in canine atopic dermatitis. Veterinary Immunology & Immunopathology — OMIA Phene_Article / Article
  • (204 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.

  • OMIM:603165 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605803 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605804 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605805 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605844 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605845 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613064 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613518 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613519 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1994. 207 Intracutaneous Tests in Dogs with Suspicion of Atopic Dermatitis. Kleintierpraxis — OMIA Phene_Article / Article
  • 1996. Langerhans cell hyperplasia and ige expression in canine atopic dermatitis. Archives of Dermatological Research — PubMed:PMID8919040 — OMIA Phene_Article / Article
  • 1997. Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. American Journal of Dermatopathology — PubMed:PMID9335242 — OMIA Phene_Article / Article
  • 1997. Serum and skin IgA concentrations in normal and atopic dogs. Aust Vet J — PubMed:PMID9469228 | DOI:10.1111/j.1751-0813.1997.tb11264.x — OMIA Phene_Article / Article
  • 1998. Canine atopic dermatitis - pathomechanisms and comparison of ict and elisa with monoclonal anti-ige-antibody [German]. Praktische Tierarzt — OMIA Phene_Article / Article
  • 1998. Reevaluation of diagnostic criteria of canine atopic dermatitis [French]. Revue de Medecine Veterinaire — OMIA Phene_Article / Article
  • 1999. Serum immunoglobulin E concentrations in West Highland White Terrier puppies do not predict development of atopic dermatitis. Veterinary Dermatology — OMIA Phene_Article / Article
  • 1999. Comparison of intradermal testing and serum testing for allergen-specific IgE using monoclonal IgE antibodies in 84 atopic dogs. Aust Vet J — PubMed:PMID10376096 | DOI:10.1111/j.1751-0813.1999.tb10263.x — OMIA Phene_Article / Article
  • 2000. Adherence by Staphylococcus intermedius to canine keratinocytes in atopic dermatitis. Research in Veterinary Science — PubMed:PMID10877976 | DOI:10.1053/rvsc.2000.0378 — OMIA Phene_Article / Article
  • 2000. IgE-reactivity to major Japanese cedar (Cryptomeria japonica) pollen allergens (Cry j 1 and Cry j 2) by ELISA in dogs with atopic dermatitis. Veterinary Immunology & Immunopathology — OMIA Phene_Article / Article
  • 2000. Aero-allergens in canine atopic dermatitis in southeastern Australia based on 1000 intradermal skin tests. Australian Veterinary Journal — PubMed:PMID10920777 — OMIA Phene_Article / Article
  • 2001. Peripheral blood mononuclear cell responses to Dermatophagogoides farinae in canine atopic dermatitis. Veterinary Immunology & Immunopathology — OMIA Phene_Article / Article
  • (204 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:603165 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605803 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605804 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605805 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605844 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605845 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613064 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613518 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613519 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1994. 207 Intracutaneous Tests in Dogs with Suspicion of Atopic Dermatitis. Kleintierpraxis — OMIA Phene_Article / Article
  • 1996. Langerhans cell hyperplasia and ige expression in canine atopic dermatitis. Archives of Dermatological Research — PubMed:PMID8919040 — OMIA Phene_Article / Article
  • 1997. Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. American Journal of Dermatopathology — PubMed:PMID9335242 — OMIA Phene_Article / Article
  • 1997. Serum and skin IgA concentrations in normal and atopic dogs. Aust Vet J — PubMed:PMID9469228 | DOI:10.1111/j.1751-0813.1997.tb11264.x — OMIA Phene_Article / Article
  • 1998. Canine atopic dermatitis - pathomechanisms and comparison of ict and elisa with monoclonal anti-ige-antibody [German]. Praktische Tierarzt — OMIA Phene_Article / Article
  • 1998. Reevaluation of diagnostic criteria of canine atopic dermatitis [French]. Revue de Medecine Veterinaire — OMIA Phene_Article / Article
  • 1999. Serum immunoglobulin E concentrations in West Highland White Terrier puppies do not predict development of atopic dermatitis. Veterinary Dermatology — OMIA Phene_Article / Article
  • 1999. Comparison of intradermal testing and serum testing for allergen-specific IgE using monoclonal IgE antibodies in 84 atopic dogs. Aust Vet J — PubMed:PMID10376096 | DOI:10.1111/j.1751-0813.1999.tb10263.x — OMIA Phene_Article / Article
  • 2000. Adherence by Staphylococcus intermedius to canine keratinocytes in atopic dermatitis. Research in Veterinary Science — PubMed:PMID10877976 | DOI:10.1053/rvsc.2000.0378 — OMIA Phene_Article / Article
  • 2000. IgE-reactivity to major Japanese cedar (Cryptomeria japonica) pollen allergens (Cry j 1 and Cry j 2) by ELISA in dogs with atopic dermatitis. Veterinary Immunology & Immunopathology — OMIA Phene_Article / Article
  • 2000. Aero-allergens in canine atopic dermatitis in southeastern Australia based on 1000 intradermal skin tests. Australian Veterinary Journal — PubMed:PMID10920777 — OMIA Phene_Article / Article
  • 2001. Peripheral blood mononuclear cell responses to Dermatophagogoides farinae in canine atopic dermatitis. Veterinary Immunology & Immunopathology — OMIA Phene_Article / Article
  • (204 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:603165 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605803 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605804 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605805 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605844 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605845 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613064 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613518 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613519 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Evidence (references)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • 1994. 207 Intracutaneous Tests in Dogs with Suspicion of Atopic Dermatitis. Kleintierpraxis — OMIA Phene_Article / Article
  • 1996. Langerhans cell hyperplasia and ige expression in canine atopic dermatitis. Archives of Dermatological Research — PubMed:PMID8919040 — OMIA Phene_Article / Article
  • 1997. Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. American Journal of Dermatopathology — PubMed:PMID9335242 — OMIA Phene_Article / Article
  • 1997. Serum and skin IgA concentrations in normal and atopic dogs. Aust Vet J — PubMed:PMID9469228 | DOI:10.1111/j.1751-0813.1997.tb11264.x — OMIA Phene_Article / Article
  • 1998. Canine atopic dermatitis - pathomechanisms and comparison of ict and elisa with monoclonal anti-ige-antibody [German]. Praktische Tierarzt — OMIA Phene_Article / Article
  • 1998. Reevaluation of diagnostic criteria of canine atopic dermatitis [French]. Revue de Medecine Veterinaire — OMIA Phene_Article / Article
  • 1999. Serum immunoglobulin E concentrations in West Highland White Terrier puppies do not predict development of atopic dermatitis. Veterinary Dermatology — OMIA Phene_Article / Article
  • 1999. Comparison of intradermal testing and serum testing for allergen-specific IgE using monoclonal IgE antibodies in 84 atopic dogs. Aust Vet J — PubMed:PMID10376096 | DOI:10.1111/j.1751-0813.1999.tb10263.x — OMIA Phene_Article / Article
  • 2000. Adherence by Staphylococcus intermedius to canine keratinocytes in atopic dermatitis. Research in Veterinary Science — PubMed:PMID10877976 | DOI:10.1053/rvsc.2000.0378 — OMIA Phene_Article / Article
  • 2000. IgE-reactivity to major Japanese cedar (Cryptomeria japonica) pollen allergens (Cry j 1 and Cry j 2) by ELISA in dogs with atopic dermatitis. Veterinary Immunology & Immunopathology — OMIA Phene_Article / Article
  • 2000. Aero-allergens in canine atopic dermatitis in southeastern Australia based on 1000 intradermal skin tests. Australian Veterinary Journal — PubMed:PMID10920777 — OMIA Phene_Article / Article
  • 2001. Peripheral blood mononuclear cell responses to Dermatophagogoides farinae in canine atopic dermatitis. Veterinary Immunology & Immunopathology — OMIA Phene_Article / Article
  • (204 additional references in OMIA)

Comparative medicine (human OMIM)

Derived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.

  • OMIM:603165 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605803 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605804 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605805 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605844 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:605845 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613064 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613518 (type: trait) — OMIA Group_OMIM (via OMIA_ID)
  • OMIM:613519 (type: trait) — OMIA Group_OMIM (via OMIA_ID)

verification_derived: method: derived_from_dataset source: "OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM" note: "Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose."

Sources

German Shepherd Dog — Canine atopic dermatitis (CAD) (hereditary; OMIA-verified breed predisposition)
companion-breed-healthPMID 8919040

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